Connectionists: Online Seminar: How the Connectome is changed by brain tumors and heals after tumor surgery

[Markus Butz-Ostendorf]

Dear List,

My apologies for cross-postings first of all!

I would like to draw your attention to our second online seminar on 
Connectomics. We have invited our clinical neuroimaging specialist Dr 
Yong Li from Biomax Brain Science to demonstrate how brain tumors change 
the human Connectome and how the Connectome heals after tumor surgery. 
Abstract at the end of this message. The seminar takes place online on 
Tue, 10 Nov 2020 at 3pm (CET). Participation is free of charge but 
registration is kindly requested via this link 
https://www.biomax.com/webinar

Explore NICARA yourself by registering a free demo account at 
https://ssl.biomax.de/nicara/

Kind regards,
Markus

==

*Abstract*
Brain damage such as tumors, traumatic brain injury or stroke alter the 
characteristics of the broader connectome—the map of all neural 
connections in the brain. A hot topic in ongoing research using the 
connectome approach is how brain rewiring can compensate for 
lesion-induced cognitive deficits before and after intervention. The 
site of a lesion within the connectome is critical. Damage of a node 
that acts e.g. as an integrator hub of several subnetworks is 
significantly more detrimental to cognitive functions than a damaged 
node with low connectivity or existing by-passes. Understanding brain 
rewiring in response to lesions is the major focus of clinical as well 
as computational neuroscience projects (such as The Virtual Brain) to 
pave the way for personalized medicine in neurology and related fields.

In this online seminar we will focus on brain tumors and explore their 
effects on the connectome using NICARA™. A particular image processing 
pipeline in NICARA, employing the best available open-source tools for 
image preprocessing and probabilistic fiber tracking, enabled us to 
automatically extract full brain tractography based structural 
connectome data from DTI raw images. Besides the pipeline, we will 
discuss quality control mechanisms especially designed for the 
assessment of large cohorts. As an example, data set we used the Brain 
Tumor Connectomics Data (Aerts H et al. Modeling Brain Dynamics in Brain 
Tumor Patients Using the Virtual Brain. eNeuro. 2018 Jun 4;5(3): 
ENEURO.0083-18.2018.) and assessed alterations in major white matter 
fiber tracts before and after surgery. For quantification, provided not 
only the abstract presentation of digitalized connectome networks in MNI 
space by a 3D lattice graphs but also offered fiber density maps 
directly in the patient’s native T1w for a precise judgement of fiber 
pathway density distribution in the vicinity of, and remote to, a tumor.

Our clinical neuroimaging specialist Dr. Yong Li will further show how 
he uses NICARA to explore, manage and compare extracted connectome 
networks for group comparisons, individual patient-matched controls 
comparisons and longitudinal assessments. NICARA is a novel neuroimaging 
tool created by clinical neuroimaging scientists for clinical and 
translational neuroscience users. A technical introduction by product 
manager Dr. Markus Butz-Ostendorf at the end of the seminar on how 
NICARA stores and retrieves connectome information using of knowledge 
models will complement the scientific presentation.

The seminar will take place on November 10, 2020 at 3:00 p.m. (CET) and 
will last about 45 minutes. Make use of this opportunity and register 
today at www.biomax.com/webinar.

Next seminar for Pharmacologists :
1/12/2020, 3:00 pm      


To register, please go to https://www.biomax.com/webinar and request 
your access data via the webinar page.


We are looking forward to meeting you.

-- 
Dr. rer. nat. Markus Butz-Ostendorf
Innovation Manager Brain Science
Senior Product Manager
Biomax Informatics AG
Robert-Koch-Str. 2, 82152 Planegg, Germany
Registergericht: Amtsgericht München, HRB 134442
Vorstand: Dr. Klaus Heumann
Vorsitzender des Aufsichtsrates: Prof. Dr. Hans-Werner Mewes
Tel: +49 89 895574-862
Fax: +49 89 895574-825
Email:markus.butz-ostendorf at biomax.com
Website:http://www.biomax.com
PGP:https://ssl.biomax.de/pgp/


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