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Dear List,<br>
<br>
My apologies for cross-postings first of all!<br>
<br>
I would like to draw your attention to our second online seminar on
Connectomics. We have invited our clinical neuroimaging specialist
Dr Yong Li from Biomax Brain Science to demonstrate how brain tumors
change the human Connectome and how the Connectome heals after tumor
surgery. Abstract at the end of this message. The seminar takes
place online on Tue, 10 Nov 2020 at 3pm (CET). Participation is free
of charge but registration is kindly requested via this link
<a class="moz-txt-link-freetext" href="https://www.biomax.com/webinar">https://www.biomax.com/webinar</a><br>
<br>
Explore NICARA yourself by registering a free demo account at
<a class="moz-txt-link-freetext" href="https://ssl.biomax.de/nicara/">https://ssl.biomax.de/nicara/</a><br>
<br>
Kind regards,<br>
Markus<br>
<br>
==<br>
<br>
<b>Abstract</b><br>
Brain damage such as tumors, traumatic brain injury or stroke alter
the characteristics of the broader connectome—the map of all neural
connections in the brain. A hot topic in ongoing research using the
connectome approach is how brain rewiring can compensate for
lesion-induced cognitive deficits before and after intervention. The
site of a lesion within the connectome is critical. Damage of a node
that acts e.g. as an integrator hub of several subnetworks is
significantly more detrimental to cognitive functions than a damaged
node with low connectivity or existing by-passes. Understanding
brain rewiring in response to lesions is the major focus of clinical
as well as computational neuroscience projects (such as The Virtual
Brain) to pave the way for personalized medicine in neurology and
related fields.<br>
<br>
In this online seminar we will focus on brain tumors and explore
their effects on the connectome using NICARA™. A particular image
processing pipeline in NICARA, employing the best available
open-source tools for image preprocessing and probabilistic fiber
tracking, enabled us to automatically extract full brain
tractography based structural connectome data from DTI raw images.
Besides the pipeline, we will discuss quality control mechanisms
especially designed for the assessment of large cohorts. As an
example, data set we used the Brain Tumor Connectomics Data (Aerts H
et al. Modeling Brain Dynamics in Brain Tumor Patients Using the
Virtual Brain. eNeuro. 2018 Jun 4;5(3): ENEURO.0083-18.2018.) and
assessed alterations in major white matter fiber tracts before and
after surgery. For quantification, provided not only the abstract
presentation of digitalized connectome networks in MNI space by a 3D
lattice graphs but also offered fiber density maps directly in the
patient’s native T1w for a precise judgement of fiber pathway
density distribution in the vicinity of, and remote to, a tumor.<br>
<br>
Our clinical neuroimaging specialist Dr. Yong Li will further show
how he uses NICARA to explore, manage and compare extracted
connectome networks for group comparisons, individual
patient-matched controls comparisons and longitudinal assessments.
NICARA is a novel neuroimaging tool created by clinical neuroimaging
scientists for clinical and translational neuroscience users. A
technical introduction by product manager Dr. Markus Butz-Ostendorf
at the end of the seminar on how NICARA stores and retrieves
connectome information using of knowledge models will complement the
scientific presentation.<br>
<br>
The seminar will take place on November 10, 2020 at 3:00 p.m. (CET)
and will last about 45 minutes. Make use of this opportunity and
register today at <a class="moz-txt-link-abbreviated" href="http://www.biomax.com/webinar">www.biomax.com/webinar</a>.<br>
<br>
Next seminar for Pharmacologists :<br>
1/12/2020, 3:00 pm <br>
<br>
<br>
To register, please go to <a class="moz-txt-link-freetext" href="https://www.biomax.com/webinar">https://www.biomax.com/webinar</a> and request
your access data via the webinar page.<br>
<br>
<br>
We are looking forward to meeting you.<br>
<br>
<pre class="moz-signature">--
Dr. rer. nat. Markus Butz-Ostendorf
Innovation Manager Brain Science
Senior Product Manager
Biomax Informatics AG
Robert-Koch-Str. 2, 82152 Planegg, Germany
Registergericht: Amtsgericht München, HRB 134442
Vorstand: Dr. Klaus Heumann
Vorsitzender des Aufsichtsrates: Prof. Dr. Hans-Werner Mewes
Tel: +49 89 895574-862
Fax: +49 89 895574-825
<a class="moz-txt-link-abbreviated" href="mailto:Email:markus.butz-ostendorf@biomax.com">Email:markus.butz-ostendorf@biomax.com</a>
Website:<a class="moz-txt-link-freetext" href="http://www.biomax.com">http://www.biomax.com</a>
PGP:<a class="moz-txt-link-freetext" href="https://ssl.biomax.de/pgp/">https://ssl.biomax.de/pgp/</a>
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