Connectionists: PhD studentship available/machine learning and bioinformatics

[C Campbell]

The Intelligent Systems Group, University of Bristol has a fully funded PhD
studentship available, to start in September/October 2016.
The deadline for applications is *** 10th June 2016 ***.

Project title: Novel Methodology for Predicting the Effects of Genetic
Variation.

Project details: Rapid developments in next-generation sequencing
technologies have led to a substantial increase in identified genetic
variants, which may be implicated in human disease. A focus of the project
is to construct and use algorithmically-based methods for predicting the
functional consequence of genetic variation. A representative publication
is available as H.A. Shihab et al. Bioinformatics
doi:10.1093/bioinformatics/btv009 (2015).
We have devised predictors for short insertions and deletions of genetic
code (indels.biocompute.org.uk), haploinsufficiency and many other
contexts.  In this PhD programme we will extend this study in many
directions including devising disease-specific predictors and devising
predictors for other types of genetic variation. The appointment should
also be happy to work with biologists who work with genetically related
data and our
team is a member of the Genomics England (100,000 genomes) Programme. In
addition to this application core, the PhD student should be interested in
the development of improved methodology for handling problems specific to
the application domain. This includes new methods for handling label noise,
improved methods for data integration, target ranking, label dependency and
a range of other issues. He or she should be capable of developing novel
methodology in addition to having a keen interdisciplinary interest in the
given medical application domain. Thus the studentship would be of interest
to an applicant with a background in mathematics, statistics,
computer science or bioinformatics.

Supervisors: Dr. Colin Campbell (C.Campbell at bristol.ac.uk) and Dr. Tom
Gaunt (Tom.Gaunt at bristol.ac.uk)

Applications: Applicants should hold (or expect to obtain) a minimum
upper-second honours degree (or equivalent) in mathematics, statistics,
computer science or bioinformatics.

The project is available to UK/EU nationals only due to the nature of the
funding and is due to start September/October 2016.
For EU nationals we are only able to pay tuition fees and not maintenance.

Any enquiries relating to the project and/or suitability should be directed
to Colin Campbell (C.Campbell at bris.ac.uk)

Administrative contact and how to apply:
http://www.bris.ac.uk/engineering/graduate-school/pg-open/funding/

Applications portal
https://webcentre.hobsons.co.uk/

Contact point for queries:
Postgraduate Admissions Team Phone: +44 (0) 117 954 5130
Email: fen-pgadmissions at bristol.ac.uk

PhD in Engineering Mathematics
Postgraduate Admissions Team
University of Bristol
Queen's Building
University Walk
Bristol
BS8 1TR, UK
-

Colin Campbell

Director, Intelligent Systems Laboratory,
Room 2.39, Merchant Venturer's Building,
University of Bristol,
Bristol BS8 1UB,
United Kingdom

*Tel:* +44 (0) 117-33-15620

*E-mail:* C.Campbell at bristol.ac.uk

http://seis.bris.ac.uk/~enicgc/
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