Workshop on Modeling Brain Disorders
Eithan Rupin
ruppin at math.tau.ac.il
Tue Mar 14 08:39:30 EST 1995
NEURAL MODELING OF COGNITIVE AND BRAIN DISORDERS
Workshop, June 8 - 10, 1995
Inn and Conference Center, University of Maryland, College Park, MD
(located just north of Washington, DC)
SPONSORS
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
National Institute on Deafness and Other Communication Disorders
National Institute on Aging
Institute for Advanced Computer Studies, University of Maryland
Dept. of Neurology, University of Maryland School of Medicine
Center for Neural Basis of Cognition, Carnegie Mellon & Pittsburgh Universities
Adams Super Center for Brain Studies, Tel Aviv University
Center for Neural and Cognitive Sciences, University of Maryland
The focus of this workshop will be on the lesioning of neural network
models to study disorders in neurology, neuropsychology and psychiatry.
The goals of the workshop are:
to evaluate current achievements and the possibilities
for further advancement;
to examine methodological modeling issues, such as limitations
of the networks currently employed, and the required computational
properties of future models; and
to make the material presented at the workshop available to the wider
audience of researchers interested in studying neural models of
brain disorders.
A Proceedings consisting of the abstracts of presentations will be available
at the meeting, and a book of contributed chapters based on the workshop is
under consideration.
Program Committee: Rita Berndt (Maryland), Barry Gordon (Johns Hopkins),
Michael Hasselmo (Harvard), Ralph Hoffman (Yale), Joanne Luciano (Boston),
Jay McClelland (Carnegie Mellon), Al Nigrin (American),
David Plaut (Carnegie Mellon), James Reggia (Maryland),
Eytan Ruppin (Tel-Aviv), and Stanley Tuhrim (Mount Sinai).
Travel Fellowships: Funding has been requested for a
few fellowships to offset travel costs of students, postdocs, and
residents. To be considered for any such travel support that
becomes available, please send your name, address, phone number,
fax number, email address, status (student/postdoc/resident) and
proof of status (copy of current student ID, letter from faculty
advisor, etc.) to reach J. Reggia at the address below by Wednesday,
April 19, 1995. Either indicate the name of the oral/poster
presentation of which you are a co-author, or state in two or
three sentences why you wish to attend.
Registration and Hotel Reservations: Please use attached forms. Registration
and reservations prior to May 15 are strongly recommended.
Questions?
Direct questions about workshop registration or administration to
Cecilia Kullman, UMIACS, University of Maryland, College Park, MD
20742 USA; Tel.: (301)405-6722; Fax: (301)314-9658; email:
cecilia at umiacs.umd.edu
For questions about hotel reservations, please contact the hotel
directly as indicated on the reservation form.
For questions about the content of the workshop,
please contact either Eytan Ruppin via email
at ruppin at math.tau.ac.il, or James Reggia, Dept. of Computer Science,
A.V. Williams Bldg., University of Maryland, College Park MD 20742 USA;
Tel.: (301) 405-2686; Fax: (301)405-6707; email: reggia at cs.umd.edu
PROGRAM
Each workshop session will be
focused on specific disorders and composed of four invited
presentations followed by a critical commentary and a general
discussion.
----- Thursday, June 8
8:00 AM: Registration Desk Opens
9:00 AM: Welcome: NIH Representative
9:05 AM: Introduction: James Reggia, University of Maryland
9:30 AM: Alzheimer's Disease and Memory Disorders
Chair and Discussant: Steven Small (University of Pittsburgh)
James McClelland (Carnegie Mellon University), with B. McNaughton
and R. O'Reilly - Complementary learning systems in the hippocampus
and neocortex
Michael Hasselmo (Harvard University) - A computational theory of Alzheimer's
disease as a breakdown in cortical learning dynamics
David Horn (Tel-Aviv University, Israel), with N. Levy and E. Ruppin -
Neural modeling of memory deterioration in Alzheimer's disease
Martha Farah (University of Pennsylvania), with L. Tippett -
Semantic knowledge impairments in Alzheimer's disease: insights
from connectionist modeling
12:30 PM: Lunch Break
2:00 PM: Epilepsy
Chair and Discussant: Michael Rogawski (National Institutes of Health)
Roger Traub (IBM Watson), with J. Jeffreys -
Unifying principles in epileptic after-discharges in vitro
John Rinzel (National Institutes of Health) - Modeling network
rhythmogenesis of epilepsy using reduced Hodgkin-Huxley neurons
William Lytton (University of Wisconsin) - Toward rational
pharmacotherapeutics
Mayank Mehta (University of Arizona), with C. Dasgupta and
G. Ullal - A neural network model for kindling of focal epilepsy
5:00 PM: Break (Put up posters)
5:30 PM: Reception and Poster Presentations
----- Friday, June 9
9:00 AM: Stroke and Functional Effects of Focal Lesions
Chair and Discussant: Barry Gordon (Johns Hopkins University)
John Pearson (David Sarnoff Research Center) - Plasticity in the
organization of adult somatosensory cortex: a computer simulation
based on neuronal group selection
James Reggia (University of Maryland), with S. Armentrout,
S. Goodall, Y. Chen, and E. Ruppin - Modeling post-stroke
cortical map reorganization
Manfred Spitzer (University of Heidelberg, Germany) - A neuronal
network model of phantom limbs
Eytan Ruppin (Tel-Aviv University, Israel), with J. Reggia -
Patterns of damage in associative memory models and
multi-infarct dementia
Noon: Lunch Break
1:30 PM: Aphasia and Acquired Dyslexia
Chair and Discussant: Rita Berndt (University of Maryland)
Gary Dell (University of Illinois), with M. Schwartz, N. Martin,
E. Saffran and D. Gagnon - Lesioning a connectionist model
of lexical retrieval to simulate naming errors in aphasia
Max Coltheart (Macquarie University, Australia), with
R. Langdon and M. Haller - Simulation of
acquired dyslexias by the DRC model, a computational model of visual
word recognition and reading aloud
Karalyn Patterson (MRC, Applied Psychology Unit, Cambridge, England),
with D. Plaut, J. McClelland, M. Seidenberg and J. Hodges -
Connections and disconnections: a connectionist account of surface dyslexia
David Plaut (Carnegie Mellon University) - Connectionist modeling
of the breakdown and recovery of reading via meaning
4:30 PM: Dinner Break
----- Saturday, June 10
9:00 AM: Schizophrenia, Frontal and Affective Disorders
Chair and Discussant: Jonathan Cohen (Carnegie Mellon University \&
University of Pittsburgh)
Ralph Hoffman (Yale University) - Modeling positive symptoms of
schizophrenia using attractor and backpropagation networks
David Servan-Schreiber (University of Pittsburgh), with J. Cohen -
Cognitive deficits in schizophrenia: modeling neuromodulation of
prefrontal cortex
Dan Levine (University of Texas at Arlington) - Functional deficits of
frontal lobe lesions
Joanne Luciano (Boston University), with M. Negishi, M. Cohen,
and J. Samson - A dynamic neural model of cognitive and
brain disorders
Noon: Lunch Break
1:30 PM: Commentary: James McClelland (Carnegie
Mellon University)
2:00 PM: General Discussion A brief commentary will be followed by a
general discussion of where we are and where we want to go from here.
Among the issues to be considered are the successes and limitations of
current models of neurological, neuropsychological and psychiatric disorders.
What common methods have been identified? How can models of this sort be
validated, and at what ``level of detail" should they be formulated?
What topics seem amenable to future neural modeling, and what are barriers
to further progress in this field? Finally, feedback on the workshop format
and content will be solicited, and the interest and usefulness of holding
similar workshops or more formal conferences in the future will be assessed.
4:30 PM: Adjournment
POSTER PRESENTATIONS
Thursday, June 8, 5:30 PM
T.S. Braver, J.D. Cohen and D. Servan-Schreiber.
A Model of Normal and Schizophrenic Performance in a Task
Involving Working Memory and Inhibition.
Carnegie Mellon University and University of Pittsburgh, USA.
J.L Contreras-Vidal, H.L. Teulings and G.E. Stelmach.
A Neural Model of Spatiotemporal Neurotransmitter Dynamics
in Parkinson's Disease: Dopamine Depletion and Lesion Studies.
Arizona State University, USA.
J.T. Devlin, L.M. Gonnerman, E.S. Andersen and M.S. Seidenberg.
Modeling Double Dissociation using Progressive, Widespread Damage.
University of Southern California, USA.
T.M. Gale, R.J. Frank, D.J. Done and S.P. Hunt.
Modeling Conceptual Disruption in Dementia of Alzheimer Type.
University of Hertfordshire, England.
P. Gupta.
Phonological Representation, Word Learning, and Verbal Short-Term
Memory: A Neural and Computational Model.
Carnegie Mellon University, USA.
B. Horwitz, A.R. McIntosh, J.V. Haxby, D. Golomb, M.B. Schapiro,
S.I. Rapoport and C.L. Grady.
Systems-Level Network Analysis of Cortical Visual Pathways Mapped
by Positron Emission Tomography (PET) in Dementia of the
Alzheimer Type. National Institute on Aging, USA.
E.A. Klein and J.C. Wu.
Neural Modeling of Striatal and Limbic Structures in Major
Depressive Illness Using PET.
University of California at Irvine, USA.
J.P. Levy.
Semantic Representations in Connectionist Models: The Use of Text
Corpus Statistics. University of Edinburgh, UK.
K.A. Mayall and G.W. Humphreys.
A Connectionist Model of Pure Alexia and Case Mixing Effects.
University of Birmingham, England.
B.F. O'Donnell, M.E. Karapelou, D. Pedini and R.W. McCarley.
Visual Pattern Classification and Recognition in Normal and
Schizophrenic Subjects: An Adaptive Resonance Theory Simulation
Study. Harvard University and Boston University, USA.
R.L. Ownby.
A Computational Model of Stroke-related Hemineglect: Preliminary
Development. University of Miami, USA.
D.V. Reynolds, H.A. Getty and G. Atwell.
Object-Oriented Computer Models of Brain Disorders Based on
Functional Neuroanatomy.
Henry Ford Hospital, USA, and University of Windsor, Canada.
R. Shilcock and P. Cairns.
Connectionist Modelling of Visuospatial Unilateral Neglect.
University of Edinburgh, UK.
R. Shilcock, M.L. Kelly and K. Loughran.
Evidence for a Connectionist Model of Visuospatial Neglect based on
Foveal Splitting. University of Edinburgh, UK.
S. Tsumoto and H. Tanaka.
Computational Analysis of Acquired Dyslexia of Chinese Characters
based on Neural Networks.
Medical Research Institute, Tokyo Medical University, Japan.
J. Sirosh and R. Miikkulainen.
Reorganization of Lateral Interactions and Topographic Maps
Following Cortical Lesions.
University of Texas at Austin, USA.
J.P. Sutton.
Modeling Cortical Disorders using Nested Networks.
Harvard University, USA.
C.S. Whitney, R.S. Berndt and J.A. Reggia.
A Computational Model of Single Word Oral Reading.
University of Maryland, USA.
J. Wright and K. Ahmad.
The Simulation of Acquired Language Disorders Using Modular
Connectionist Architectures.
University of Surrey, UK.
DIRECTIONS TO UNIVERSITY OF MARYLAND INN AND CONFERENCE CENTER
>From National (DCA) Airport:
Upon leaving the airport, follow the signs to Washington, D.C.,
using the George Washington Parkway. Stay on the parkway until
you see the I-495 Rockville exit. Follow 495 until you get to
the New Hampshire Avenue exit. Take the New Hampshire/Takoma Park
exit. Stay on New Hampshire Avenue and make a left at the second
light onto Adelphi Road. Drive approximately three miles on Adelphi
Road through two traffic lights. At the third light, make a left
turn onto University Boulevard and an immediate right into the
parking garage. The building is marked University College
Center of Adult Education.
>From Baltimore-Washington International (BWI) Airport:
Upon exiting the airport, follow signs for I-95 (toward Washington).
I-95 will take you to 95 South. Follow 95 South approximately
30 miles. Stay on 95 South until you get to the Route 1
South/College Park exit (Exit 25B). Follow Route 1 to the
first exit for the University of Maryland (Systems Administration).
Take this exit (Route 193) which immediately becomes University Boulevard.
Keep on University Boulevard and go through two traffic lights.
At the third light (intersection of University Boulevard and Adelphi
Road) make a U-turn and an immediate right into the parking garage.
The building is marked University College Center of Adult Education.
>From Dulles (IAD) Airport:
Upon leaving the airport, follow the signs towards Washington, D.C.,
until you see the signs for I-495. Take the exit towards Rockville.
Follow 495 until you get to the exit for New Hampshire Avenue.
Take the New Hampshire/Takoma Park exit. Stay on New Hampshire
Avenue and make a left at the second light onto Adelphi Road.
Drive approximately three miles on Adelphi Road through two traffic
lights. At the third light, make a left turn onto University
Boulevard and an immediate right into the parking garage.
The building is marked University College Center of Adult Education.
----------------------------cut here-------------------------------
REGISTRATION FORM
NEURAL MODELING WORKSHOP
College Park, Md
June 8-10, 1995
Name: ___________________________________________________
Affiliation: ________________________________________________
Address: _________________________________________________
_________________________________________________________
Telephone: ___________________________
Fax: ________________________________
e-mail: ______________________________
___ $50 Conference fee before 5/15/95
___ $65 Conference fee after 5/15/95
___ $25 Student/postdoc/resident fee
Amount Enclosed: $________________
MAKE CHECKS PAYABLE TO "UMIACS-Neural Modeling Workshop."
Conference fee includes proceedings, coffee and reception.
Payment must accompany the registration form. Checks must be
in US dollars only and payable to "UMIACS-Neural Modeling Workshop."
Please do not send cash. CREDIT CARDS WILL NOT BE ACCEPTED.
Students/postdocs/residents must provide a copy of a student
ID card or a letter from a faculty member for proof of status.
RETURN BY MAY 15, 1995 TO:
Cecilia Kullman
UMIACS
University of Maryland
College Park, MD 20742, USA
Tel.: (301) 405-6722. Fax: (301) 314-9658
e-mail: cecilia at umiacs.umd.edu
----------------------------- cut here ----------------------------
HOTEL RESERVATION FORM
Neural Modeling Workshop
The Inn and Conference Center
University of Maryland University College
Please reserve the following accommodations:
___ $69 Single Occupancy
___ $84 Double Occupancy
Arrival Date: ____________
Departure Date: ____________
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Rates are per room per night. All rates are subject to a 5% occupancy
tax. All reservations must be accompanied by a deposit of one night's
room rate plus tax, or a credit card guarantee. Guaranteed reservations
will be held until 6:00 a.m. the following day. Reservations not canceled
prior to 6:00 p.m. on the arrival day will be charged one night's room rate
plus tax.
SEND BY MAY 15, 1995 TO:
Reservations
The Inn and Conference Center
University of Maryland University College
College Park, MD 20742, USA
Tel.: (301) 985-7300, Fax: (301) 985-7850
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