Massive Intake of NIH Atherosclerotic Risk Data

[Chirag Nagpal]

Hello All

We have recently executed an agreement with the NIH's National Heart Lung
and Blood Institute to access some of the largest clinical trials and
observational studies in the NHLBI's BioLINCC repository. Access to these
cohorts puts us at an equal footing with some of the top medical schools
and biostatistics departments in the world.

We now would be able to frame a design complex epidemiological studies
including, but not limited to:

- Assessment of demographic disparities in cardiovascular health
- Causal and subgroup identification of heterogeneous benefit to the said
interventions.

The availability of these datasets would allow us to answer fundamental
questions including:

- Effect of Lipid Lowering Therapies
- Effect of Glycemic Control
- Hypertension Management
- Optimal Surgical Intervention (CABG/PCI, Delayed or Proactive)

The availability of these data also now gives us the ability of pooling
data from multiple studies to create larger cohorts to answer questions
that were previously not possible with just a single study.

The studies also make for good "real world" datasets for generic  machine
learning methodology papers.

*Our access includes baseline and follow up data from the following
studies: *

*ALLHAT*:  https://biolincc.nhlbi.nih.gov/studies/allhat/
*ACCORD*: https://biolincc.nhlbi.nih.gov/studies/accord/
*SPRINT*: Systolic Blood Pressure Intervention Trial
<https://biolincc.nhlbi.nih.gov/dataset/sprint/>
*BARI2D*: https://biolincc.nhlbi.nih.gov/studies/bari2d/
*AMIS*: https://biolincc.nhlbi.nih.gov/studies/amis/
*OAT*:  https://biolincc.nhlbi.nih.gov/studies/oat/
*ROC-CCC*: Resuscitation Outcomes Consortium (ROC) Trial Of Continuous
Compressions Versus Standard CPR In Patients With Out-Of-Hospital Cardiac
Arrest (CCC) <https://biolincc.nhlbi.nih.gov/dataset/roc_ccc/>
*ROC-ALPS*: Resuscitation Outcomes Consortium (ROC) Amiodarone, Lidocaine
or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular
Fibrillation or Ventricular Tachycardia
<https://biolincc.nhlbi.nih.gov/dataset/roc_alps/>
*PROMISE*: Prospective Multicenter Imaging Study for Evaluation of Chest
Pain <https://biolincc.nhlbi.nih.gov/dataset/promise/>
*PEACE*: Prevention of Events With Angiotensin-Converting Enzyme Inhibitor
Therapy  <https://biolincc.nhlbi.nih.gov/dataset/peace/>
*AIMHIGH*: Atherothrombosis Intervention in Metabolic Syndrome with Low
HDL/High Triglyceride and Impact on Global Health Outcomes (AIM-HIGH)
<https://biolincc.nhlbi.nih.gov/dataset/aimhigh/>
*AMIS*: Aspirin-Myocardial Infarction Study
<https://biolincc.nhlbi.nih.gov/dataset/amis/>
*BEST*: Beta-Blocker Evaluation in Survival Trial
<https://biolincc.nhlbi.nih.gov/dataset/best/>
*ENRICHD*: Enhancing Recovery in Coronary Heart Disease Patients
<https://biolincc.nhlbi.nih.gov/dataset/enrichd/>
*SOLVD*: Studies of Left Ventricular Dysfunction
<https://biolincc.nhlbi.nih.gov/dataset/solvd/>
*STICH*: Surgical Treatment for Ischemic Heart Failure
<https://biolincc.nhlbi.nih.gov/dataset/stich/>

*Observational Cohorts:*
*ARIC*: Atherosclerosis Risk in Communities Study
<https://biolincc.nhlbi.nih.gov/dataset/aric/>
*MESA*: Multi-Ethnic Study of Atherosclerosis
<https://biolincc.nhlbi.nih.gov/dataset/mesa/>
*CARDIA*: Coronary Artery Risk Development in Young Adults
<https://biolincc.nhlbi.nih.gov/dataset/cardia/>
*SHEP*: Systolic Hypertension in the Elderly Program
<https://biolincc.nhlbi.nih.gov/dataset/shep/>
*SHHS*: Sleep Heart Health Study
<https://biolincc.nhlbi.nih.gov/dataset/shhs/>

*In case any of this is of interest, please reach out. *

-- 

*Chirag Nagpal* PhD Candidate, Auton Lab
School of Computer Science
Carnegie Mellon University
cs.cmu.edu/~chiragn
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