Connectionists: REMINDER: World wide VVTNS series (6th season): June 24 2026 | From Cajal’s Spines to Digital Neurons: Connectomics View on Dendritic Computations | Idan Segev, The Hebrew University of Jerusalem

[David Hansel]

[image: VVTNS.png]
https://www.wwtns.online
<https://streaklinks.com/A9c7PbbpKY7PxB6PaAJWGD3-/https%3A%2F%2Fwww.wwtns.online>
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on twitter: wwtns at TheoreticalWide

You are cordially invited to the VVTNS Sixth Season Closing Lecture

Idan Segev
The Edmond and Lily Safra Center for Brain Sciences
The Hebrew University of Jerusalem

on the topic of

>From Cajal’s Spines to Digital Neurons:

Connectomics View on Dendritic Computations

The lecture will be held on Zoom on June 24, 2026 at *11:00 am ET *

> To receive the link: https://www.wwtns.online/register-page
>

>
*Abstract: *Dendritic spines are among the smallest structures in the
brain, yet they hold some of the deepest clues to how neurons compute and
store memories. In this lecture, I will revisit the classical question of
spine biophysics in the new age of connectomics, where nanometer-resolution
electron microscopy allows us to reconstruct whole neurons with thousands
of synapses and spines. I will show how spine density, spine-neck
resistance, and the irregular geometry of individual spines can shape local
synaptic signals, generate fast voltage dynamics, influence
excitatory/inhibitory gating, and affect communication between neighboring
spines. I will then discuss how automated reconstruction pipelines and
biophysical modeling now make it possible to build digital neurons at spine
and synapse resolution, and how AI-based approaches, such as our new
AI-based TwinProp algorithm, allow us to ask - and get answer - to a
fundamental question: what can a neuron compute? I will end by claiming
that we now enter a new age of connectomics that provides an essential
constraint on understanding how synapses, neurons, and circuits perform
their computational functions.

*About VVTNS : Launched as the World Wide  Theoretical Neuroscience Seminar
(WWTNS) in November 2020 and renamed in homage to Carl van Vreeswijk in
Memoriam (April 20, 2022), Speakers have the occasion to talk about
theoretical aspects of their work which cannot be discussed in a setting
where the majority of the audience consists of experimentalists. The
seminars, **held on Wednesdays at 11 am ET,**  are 45-50 min long followed
by a discussion. The talks are recorded with authorization of the speaker
and are available to everybody on our YouTube channel.*


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