Connectionists: New on the VVTNS YouTube channel: Computing the effects of excitatory-inhibitory balance on neuronal input-output properties | Alex Reyes, New York University

[David Hansel]

[image: VVTNS.png]

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New on the VVTNS YouTube Channel
https://www.wwtns.online/past-seminars-2025-2026

*Computing the effects of excitatory-inhibitory balance*

*on neuronal input-output properties*

lecture delivered on February 11,  2026  by

Alex Reyes

New York University


*Abstract: *In sensory systems, stimuli are represented through the diverse
firing responses and receptive fields of neurons. These features emerge
from the interaction between excitatory (E) and inhibitory (I) neuron
populations within the network. Changes in sensory inputs alter this
balance, leading to shifts in firing patterns and the input-output
properties of individual neurons and the network. While these phenomena
have been studied extensively with experiments and theory, the underlying
principles for combining E and I inputs are still unclear. Here, the rules
for probabilistically combining E and I inputs are derived that describe
how neurons in a feedforward inhibitory circuit respond to stimuli. This
simple model is broadly applicable, capturing a wide range of response
features that would otherwise require multiple separate models and offers
insights into the cellular and network mechanisms influencing the
input-output properties of neurons, gain modulation, and the emergence of
diverse temporal firing patterns.

*About VVTNS : Launched as the World Wide  Theoretical Neuroscience Seminar
(WWTNS) in November 2020 and renamed in homage to Carl van Vreeswijk in
Memoriam (April 20, 2022), Speakers have the occasion to talk about
theoretical aspects of their work which cannot be discussed in a setting
where the majority of the audience consists of experimentalists. The
seminars, **held on Wednesdays at 11 am ET,**  are 45-50 min long followed
by a discussion. The talks are recorded with authorization of the speaker
and are available to everybody on our YouTube channel.*



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