Connectionists: SCGB Global Postdoc/Student Meeting: Thursday, August 5th by Kayvon Daie

[Laura Long]

The Simons Collaboration on the Global Brain (SCGB) hosts postdoc/student
meetings to bring together trainees interested in neural coding and
dynamics to discuss ideas and data. In addition to regional meetings in New
York, Boston, and the Bay Area, SCGB holds a Global virtual series to
connect systems and computational neuroscientists across the world. We
would love to see you at this month's Global meeting! Please see event
details and Zoom link below.



SCGB Global Postdoc/Student Meeting:
https://www.eventbrite.com/e/scgb-global-postdocstudent-meeting-tickets-163885819899


Thursday, August 5th, 1pm Eastern Time

https://simonsfoundation.zoom.us/j/93637538440?pwd=MnNCeVF1eThKZmVUa2p5bUlRR3BZUT09
    Passcode: 443599




*Kayvon Daie*Research Associate, Svoboda Laboratory
HHMI's Janelia Research Campus
*Dissection of the neural circuitry underlying short-term memory*

Short-term memory is associated with persistent neural activity without
sustained input, arising from the interactions between neurons with brief
time constants. A variety of neural circuit models could account for
existing measurements of neural activity. To explore which, if any, of
these models are most consistent with neural circuitry, we measured
coupling between functionally characterized motor cortex neurons in mice
performing a memory-guided response task. Targeted two-photon
photostimulation of small (<10) groups of neurons produced sparse calcium
responses in coupled neurons over approximately 100 μm. Neurons with
similar task-related selectivity were preferentially coupled.
Photostimulation of different groups of neurons modulated activity in
different subpopulations of coupled neurons. Responses of stimulated and
coupled neurons persisted for seconds, far outlasting the duration of the
photostimuli. Photostimuli produced behavioral biases that were predictable
based on the tuning of the photostimulated population, even though
photostimulation preceded the behavioral response by seconds. Our results
suggest that memory-related neural circuits contain intercalated,
recurrently connected modules and that these modules are coupled via
long-range “hidden feedforward” connections.


*Please note that this meeting is open to all neuroscience postdocs and PhD
students, regardless of location or SCGB affiliation (sorry, no PIs). *After
Q&A with the speaker, we will open breakout rooms for anyone interested in
staying to chat, network, or further discuss the talk. In addition to these
breakouts, SCGB Scientific Staff will be available for "office hours" to
chat and answer questions about SCGB programs and support.

Registration on EventBrite is encouraged but not required:
https://www.eventbrite.com/e/scgb-global-postdocstudent-meeting-tickets-163885819899

Please contact Laura Long at llong at simonsfoundation.org with any questions.

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