Paper Available: Spike-Timing-Dependent Synaptic Plasticity

[Ken Miller]

The following paper is available as
ftp://ftp.keck.ucsf.edu/pub/ken/STDP.ps (postscript)
ftp://ftp.keck.ucsf.edu/pub/ken/STDP.ps.gz (compressed postscript)
or from my home page
http://www.keck.ucsf.edu/~ken (click on 'publications')

"Competitive Hebbian Learning Through Spike-Timing Dependent Synaptic
Plasticity", by Sen Song, Kenneth D. Miller and L. F. Abbott.  

This is a preprint (final draft) of an article that has appeared as
Nature Neuroscience 3:919-926 (2000).

ABSTRACT:

Hebbian models of development and learning require both
activity-dependent synaptic plasticity and a mechanism that induces
competition between different synapses.  Recent experiments have
characterized a form of long-term synaptic plasticity that depends on
the relative timing of pre- and postsynaptic action potentials, which
we call spike-timing dependent plasticity (STDP).  In modeling
studies, we find that this form of synaptic modification can
automatically balance synaptic strengths to make postsynaptic firing
irregular but more sensitive to presynaptic spike timing.  It has been
argued that neurons in vivo operate in such a balanced regime.
Synapses subject to STDP compete for control of the timing of
postsynaptic action potentials.  Inputs that fire the postsynaptic
neuron with short latency or that act in correlated groups are able to
compete most successfully and develop strong synapses, while the
synapses of longer latency or less effective inputs are weakened.



Ken
 
        Kenneth D. Miller               telephone: (415) 476-8217
	Associate Professor		fax: (415) 476-4929
        Dept. of Physiology, UCSF	internet: ken at phy.ucsf.edu
        513 Parnassus			www: http://www.keck.ucsf.edu/~ken
        San Francisco, CA 94143-0444