vaccine effectiveness

[Artur Dubrawski]

I thought this topic may be of broader interest to the Lab community.


This large study from Israel just got out.

It shows no increase of immunity to covid infection within the first 11
days after the first dose of Pfizer vaccine.



https://www.nature.com/articles/s41591-021-01316-7.pdf
<https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41591-021-01316-7.pdf&data=04%7C01%7C%7Ce6a2e56c4a7949860e9e08d8f36cc317%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637526995742156455%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=jELp8IJOYUDuSlabIEKGptMcN4nOko1%2Fec2s%2BL9zHSk%3D&reserved=0>



And this one from CDC shows 80% immunity 2+ weeks after either Pfizer or
Moderna's first dose, and 90% 2+ weeks after the second dose of either
vaccine.



https://www.cdc.gov/mmwr/volumes/70/wr/mm7013e3.htm
<https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cdc.gov%2Fmmwr%2Fvolumes%2F70%2Fwr%2Fmm7013e3.htm&data=04%7C01%7C%7Ce6a2e56c4a7949860e9e08d8f36cc317%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637526995742166446%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=BCfmClPXd3wfxIFybKQS2Xo5kj7aPyzSnBGGZtU3f1E%3D&reserved=0>



Unlike previous data, which was based on limited-size clinical trials
and claimed 95% effectiveness ~3-4 weeks after the second dose, those two
studies have been conducted on real-world samples, so they may carry more
practical credibility.

Both results are optimistic, however they show that we should not assume
any good effect of the vaccine and stay supersafe until at least day 12
after the first dose.


Cheers,

Artur
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