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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">The BRAIN
<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-27-004.html">Theories, Models and Methods (TMM) program</a> (RFA DA 27 004) supports the development and validation of innovative and rigorous theories, models and methods to advance the quantitative
and predictive understanding of brain function across scales, including behavior.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">The program emphasizes tools that develop novel approaches for analyzing, integrating, and interpreting large-scale, complex data emerging from the BRAIN initiative and
related efforts, including cell-type specific physiological, anatomical, connectivity, and behavioral data.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Applications should focus on one or more of the following:<o:p></o:p></span></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l2 level1 lfo1"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">new or significantly advanced
<b>theories </b>of brain function<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l2 level1 lfo1"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">mechanistic and/or predictive
<b>models</b> of neural circuit activity and behavior grounded in empirical data <o:p>
</o:p></span></li><li class="MsoNormal" style="mso-list:l2 level1 lfo1"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">novel computational or statistical
<b>methods</b> for analyzing neural and behavioral datasets. <o:p></o:p></span></li></ul>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Tools for analyzing <i>brain activity</i>
<b>must:<o:p></o:p></b></span></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l1 level1 lfo2"><b><span style="font-size:11.0pt;font-family:"Times New Roman",serif">use data with cellular and sub-second temporal resolution</span></b><span style="font-size:11.0pt;font-family:"Times New Roman",serif"> (e.g.,
single-unit recordings, cellular imaging, connectomics) OR<b> integrate information across multiple, clearly defined temporal scales </b>(e.g., from synaptic events to learning)<b>.</b> <o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo2"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Approaches relying solely on non-invasive, low-resolution signals (e.g., scalp EEG, fMRI BOLD) <b>must be directly integrated with and constrained
by cellular/circuit-level data</b>. <o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo2"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Tools for analyzing <i><u>behavior</u></i>
<b>must incorporate neural data </b>AND<b> span multiple relevant temporal scales</b>.
<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo2"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Experimental work <b>must be limited to estimating model parameters and/or testing the validity of the TMM tools being delivered.</b> <o:p></o:p></span></li></ul>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Theories, models and methods using disease or treatment paradigms are not responsive unless used to understand underlying functional and brain circuits.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Important Deadlines:<o:p></o:p></span></b></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l0 level1 lfo3"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">New submissions:
<b>October 6, 2026</b><o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l0 level1 lfo3"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Resubmission/Renewal applications:
<b>November 6, 2026</b><o:p></o:p></span></li></ul>
<p class="MsoNormal"><b><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Please send specific aims pages and inquiries to</span></b><span style="font-size:11.0pt;font-family:"Times New Roman",serif">:
<a href="mailto:BRAINTheoriesFOA@ninds.nih.gov"><b>BRAINTheoriesFOA@ninds.nih.gov.</b></a> We are happy to consult on fit with the program.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Regards,<o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Michele<o:p></o:p></span></i></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">---<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Michele Ferrante, Ph.D.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">Program Officer,
<span style="color:#0070C0"><a href="https://www.nimh.nih.gov/about/organization/dtr/adult-psychopathology-and-psychosocial-interventions-research-branch/translational-digital-and-computational-psychiatry-program"><span style="color:#0070C0;text-decoration:none">Digital
& Computational Psychiatry Program</span></a></span><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">National Institute of Mental Health<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">National Institutes of Health<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">6001 Executive Blvd, North Bethesda, MD 20852, Rm 6233<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:#0070C0"><a href="https://outlook.office.com/bookwithme/user/a331ae09be8247768979e9279dc478ce@nih.gov?anonymous&ep=bwmEmailSignature"><span style="color:#0070C0;text-decoration:none">Book
a meeting</span></a></span><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:#0F9ED5"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><a href="https://commonfund.nih.gov/primed-ai/news/apply-nih-common-fund-primed-ai-funding-opportunities"><span style="color:windowtext;text-decoration:none"><img border="0" width="457" height="91" style="width:4.7604in;height:.9479in" id="Picture_x0020_2" src="cid:image001.png@01DD3A1B.83DDEBB0"></span></a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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