<div dir="ltr"><div class="gmail_quote gmail_quote_container"><br><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr" class="gmail_attr" style="text-align:center"><img src="cid:ii_l25sulo01" alt="VVTNS.png" width="236" height="236" style="margin-right:0px"></div><div dir="ltr" class="gmail_attr" style="text-align:center"><a href="https://streaklinks.com/A9c7PbbpKY7PxB6PaAJWGD3-/https%3A%2F%2Fwww.wwtns.online" style="font-size:large" target="_blank">https://www.wwtns.online</a><span style="font-size:large"> - on twitter: wwtns@TheoreticalWide</span></div><div dir="ltr" class="gmail_attr" style="text-align:center"><font size="4"><br></font></div><div dir="ltr" class="gmail_attr" style="text-align:center"><font size="4">You are cordially invited to </font><span style="font-size:large"> the lecture</span></div><div dir="ltr" class="gmail_attr" style="text-align:center"><span style="font-family:helvetica-w01-roman,helvetica-w02-roman,helvetica-lt-w10-roman,sans-serif;background-color:transparent;font-size:18px"><font color="#000000"><br></font></span></div><div dir="ltr" class="gmail_attr" style="text-align:center"><p style="background:transparent;border:0px;outline:0px;padding:0px;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:18px;line-height:1.6em;font-family:spinnaker,sans-serif;margin:0px"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline;font-family:helvetica-w01-roman,helvetica-w02-roman,helvetica-lt-w10-roman,sans-serif"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline"><font color="#000000">Katharina Anna Wilmes</font></span></span></span></p><p style="background:transparent;border:0px;outline:0px;padding:0px;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:18px;line-height:1.6em;font-family:spinnaker,sans-serif;margin:0px"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline;font-family:helvetica-w01-roman,helvetica-w02-roman,helvetica-lt-w10-roman,sans-serif"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline"><font color="#000000">Institute of Neuroinformatics</font></span></span></span></p><p style="background:transparent;border:0px;outline:0px;padding:0px;vertical-align:baseline;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;font-size-adjust:none;font-kerning:auto;font-feature-settings:normal;font-stretch:normal;font-size:18px;line-height:1.6em;font-family:spinnaker,sans-serif;margin:0px"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline;font-family:helvetica-w01-roman,helvetica-w02-roman,helvetica-lt-w10-roman,sans-serif"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline"><font color="#000000">Zurich</font></span></span></span></p></div><div dir="ltr" class="gmail_attr" style="text-align:center"><font color="#000000" style="background-color:transparent"><br></font></div><div dir="ltr" class="gmail_attr" style="text-align:center"><font color="#000000" style="background-color:transparent"> </font><span style="background-color:transparent;font-size:large;color:rgb(0,0,0)">on the topic of </span></div><div dir="ltr" class="gmail_attr" style="text-align:center"><span style="background-color:transparent;font-family:spinnaker,sans-serif;font-size:20px"><font color="#000000"><br></font></span></div><div dir="ltr" class="gmail_attr" style="text-align:center"><span style="font-family:spinnaker,sans-serif;font-size:20px"><font color="#000000">Uncertainty-aware predictive processing </font></span></div><div dir="ltr" class="gmail_attr" style="text-align:center"><span style="background-color:transparent;color:rgb(0,0,0);font-family:spinnaker,sans-serif;font-size:20px"><br></span></div><div dir="ltr" class="gmail_attr" style="text-align:center"><font size="4">The lecture will be held on zoom on November 12, 2025, at <u><b>11:00 am ET </b></u>  </font></div><div dir="ltr" class="gmail_attr" style="text-align:center"><font size="4"><br></font></div><div dir="ltr" class="gmail_attr" style="text-align:center"><span style="font-size:large">To receive the link: </span><a href="https://www.wwtns.online/register-page" style="font-size:large" target="_blank">https://www.wwtns.online/register-page</a><font size="4"> </font><font size="4"> </font> </div><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr"><div class="gmail_quote"><div class="gmail_quote"><div dir="ltr"><p style="text-align:center"><br></p></div></div></div></div></blockquote><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div style="text-align:center"><font size="4" color="#000000"> </font></div><div><span style="font-family:spinnaker,sans-serif;font-size:14px;text-align:justify"><font color="#000000"><b>Abstract: </b></font></span><font color="#000000"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline;font-family:spinnaker,sans-serif;font-size:14px;text-align:justify"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline">Minimising cortical prediction errors is thought to be a key computation underlying perception, action, and learning. Yet, how the cortex represents and uses uncertainty in this process remains unclear. In the first part of this talk, I will present a normative framework showing how uncertainty can modulate prediction error activity to yield uncertainty-modulated prediction errors (UPEs), hypothesised to be represented by layer 2/3 pyramidal neurons. We propose that these UPEs are computed through inhibitory mechanisms involving SST and PV interneurons. A circuit model demonstrates how cortical cell types can locally compute means, variances, and UPEs, leading to adaptive learning rates. In</span></span><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline;font-family:spinnaker,sans-serif;font-size:14px;text-align:justify"><span style="background:transparent;border:0px;margin:0px;outline:0px;padding:0px;vertical-align:baseline"> the second part, I will discuss how uncertainty modulation could be controlled by higher-level representations. We formally derived neural dynamics that minimise prediction errors under the assumption that cortical areas must not only predict the activity in other areas and sensory streams but also jointly project their inverse expected uncertainty about their predictions, which we call “confidence”. This yields a confidence-weighted integration of bottom-up and top-down signals, consistent with Bayesian principles, and predicts the existence of second-order errors that compare confidence with performance. We predict that these second-order errors propagate alongside classical prediction errors through the cortical hierarchy, and simulations demonstrate that this mechanism enables nonlinear classification within a single cortical area.</span></span></font></div><div><span style="font-family:spinnaker,sans-serif;font-size:14px;text-align:justify"><font color="#000000"><br></font></span></div><div><div><i style="background-color:transparent;color:rgb(80,0,80)"><font color="#000000"><span style="font-family:helvetica-w01-light,helvetica-w02-light,sans-serif;text-align:justify"><b>About VVTNS :</b> Launched as the World Wide  Theoretical Neuroscience Seminar (WWTN</span><span style="font-family:helvetica-w01-light,helvetica-w02-light,sans-serif;text-align:justify">S) in N</span></font><span style="color:rgb(0,0,0);font-family:helvetica-w01-light,helvetica-w02-light,sans-serif;text-align:justify">ovember 2020 and renamed in homage to Carl van Vreeswijk in Memoriam (April 20, 2022), Speakers have the occasion to talk about theoretical aspects of their work which cannot be discussed in a setting where the majority of the audience consists of experimentalists. The seminars, </span></i><i style="background-color:transparent;color:rgb(80,0,80)"><span style="color:rgb(0,0,0);font-family:helvetica-w01-light,helvetica-w02-light,sans-serif;text-al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