<div dir="ltr"><div><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif"><span class="gmail_default" style="font-size:large"></span></span><span class="gmail_default" style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif">O</span><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif">ur paper "IRMA: Machine learning-based harmonization of 18F-FDG PET brain scans in multi-center studies" </span></div><div><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif">b<span class="gmail_default" style="font-size:large"></span><span class="gmail_default" style="">y Sofie Lövdal et al. </span>has been published in <span class="gmail_default" style="">the E</span>uropean<span class="gmail_default" style="font-size:large"> J</span>ournal of Nuclear Medicine and Molecular Imaging<span class="gmail_default" style="font-size:large"> </span></span></div><div>and is available online <span class="gmail_default" style="font-size:large"></span>(open access):</div><div><div class="gmail_default" style=""><a href="https://link.springer.com/article/10.1007/s00259-025-07114-4">https://link.springer.com/article/10.1007/s00259-025-07114-4</a></div><div class="gmail_default" style=""><br></div><div class="gmail_default" style="">In this work we apply interpretable machine learning systems for the analysis of 18-FDG PET</div><div class="gmail_default" style="">brain scans from different medical centers. W<span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">e show that the center origin of healthy control brain  </span></div><div class="gmail_default" style=""><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">images acquired with different </span><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">scanners/protocols can be identified with high confidence. Consequently,</span></div><div class="gmail_default" style=""><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">machine learning models  </span><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">trained with data from different scanners may be heavily impacted by this </span></div><div class="gmail_default" style=""><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">bias when applied to a clinically  </span><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">relevant problem, e.g. the differential diagnosis of neurodegenerative</span></div><div class="gmail_default" style=""><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">disorders. We propose IRMA (Iterated Relevance Matrix Analysis)  </span><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">as a recursive method to learn </span><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">and </span></div><div class="gmail_default" style=""><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">disregard bias in PET feature vectors. Related code </span><span style="color:rgba(0,0,0,0.9);font-family:-apple-system,system-ui,"system-ui","Segoe UI",Roboto,"Helvetica Neue","Fira Sans",Ubuntu,Oxygen,"Oxygen Sans",Cantarell,"Droid Sans","Apple Color Emoji","Segoe UI Emoji","Segoe UI Emoji","Segoe UI Symbol","Lucida Grande",Helvetica,Arial,sans-serif;font-size:22.75px">is freely available at  </span></div><div class="gmail_default" style=""><a href="https://github.com/SofieLovdal/IRMA-harmonization">https://github.com/SofieLovdal/IRMA-harmonization</a></div><div class="gmail_default" style=""><br></div></div><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div>---------------------------------------------------<br></div>
<div>Prof. Dr. Michael Biehl</div>
<div>Bernoulli Institute for Mathematics, </div><div>Computer Science & Artificial Intelligence</div>
<div>P.O. Box 407, 9700 AK Groningen, NL</div>
<div>https://<a href="http://www.cs.rug.nl/~biehl" target="_blank">www.cs.rug.nl/~biehl</a>     <a href="mailto:m.biehl@rug.nl" target="_blank">m.biehl@rug.nl</a></div></div></div></div></div></div></div></div>