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<p class="MsoNormal" align="center" style="text-align:center"><img width="130" height="153" style="width:1.35in;height:1.5958in" id="Picture_x0020_4" src="cid:image001.png@01DB40B4.637B7D90"><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><a href="https://www.linkedin.com/company/essex-bcine-lab/"><span style="font-size:18.0pt">https://www.linkedin.com/company/essex-bcine-lab/</span></a><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><o:p> </o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:black">The Essex BCI-NE Lab invites you to join our next monthly webinar:<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:black">Human intracranial dynamics of real-world and imagined navigation</span></b><span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:black">
<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:black">Delivered by<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:black">Dr Martin Seeber<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center">(UCLA)<o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><o:p> </o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:13.5pt">The webinar will take place over Zoom on Wednesday, 4<sup>th</sup> December 2024, at 4pm UK time </span> <o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:18.0pt">RSVP: </span><a href="https://www.linkedin.com/events/essexbci-newebinarspresentsdrma7267475161174401025/about/"><span style="font-size:18.0pt">https://www.linkedin.com/events/essexbci-newebinarspresentsdrma7267475161174401025/about/</span></a>
<o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:13.5pt;color:black"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:13.5pt;color:black">Abstract</span></b><b><span style="font-size:13.5pt;font-family:"Garamond",serif;color:black">: </span></b><span style="font-size:11.0pt;color:black">Recollecting past events is crucial for
understanding episodic memory and anticipating future behaviors. Previous research in freely-moving rodents proposed a central role of the medial temporal lobe’s (MTL) involvement in spatial navigation and memory formation. Here, we study whether real-world
and imagined navigation elicits functional similarities in the human MTL.<br>
Taking advantage of recent neurotechnological developments, we examined intracranial electroencephalography (iEEG) recorded from five freely-moving humans. Participants learned to navigate two routes in an indoor room (14.6 × 13.5 m2) equipped with motion capture.
After each real-world walk, participants walked on a treadmill while imagining walking these routes in their minds. Transient theta oscillations were evident in each participant at spectral peaks in the 4-9 Hz frequency range. These short-lasting theta bouts
frequently occurred prior to upcoming turns and consistently occurred across trials. During imagined navigation, we found theta bouts at specific time points resembling the routes’ geometry, similar to the real-world dynamics.<br>
We subsequently used these theta dynamics as priors to analyze scalp EEG components related to the intracranial data. EEG source imaging revealed component generators at the actual implantation sites and in remote areas, such as the prefrontal cortex, functionally
linked to medial temporal lobe dynamics. These findings open up novel possibilities for studying human MTL interactions with cortical areas in freely behaving and imagining humans. Altogether, our results open novel avenues for studying real-world spatial
navigation, episodic memory, and imaginable future behaviors.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt;color:black">Speaker Biography</span></b><span style="font-size:11.0pt;color:black">: Martin obtained his PhD at Graz University of Technology, studying neural correlates of self-movement, especially gait.
Afterward, he joined the basic neuroscience department at Campus Biotech in Geneva, Switzerland, to investigate intrinsic, spontaneous brain dynamics by combining intracranial and scalp electroencephalography. At UCLA, he aims to better understand neural dynamics
related to movement trajectories and the formation of episodic knowledge with the aid of intracranial EEG and full-body motion capture.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:black">Profile on Google Scholar:
<a href="https://scholar.google.com/citations?user=NFI7NlgAAAAJ" target="_blank">
https://scholar.google.com/citations?user=NFI7NlgAAAAJ</a></span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">The <b>Essex BCI-NE Lab webinars series</b> takes place on the first or second Wednesday of the month over Zoom and are open to all. Speakers are invited to talk about their research for 45-50 minutes followed by a Q&A session/discussion.
<o:p></o:p></p>
<p class="MsoNormal">Where speakers allow it, we record the talks and make them available to everyone on our YouTube channel. You can watch previous talks at:
<a href="https://www.youtube.com/@essexbcis">https://www.youtube.com/@essexbcis</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Next speakers:<o:p></o:p></p>
<ul style="margin-top:0cm" type="disc">
<li class="MsoListParagraph" style="margin-left:0cm;mso-list:l0 level1 lfo1">Jon Wolpaw (January 2025) -
<a href="https://scholar.google.com/citations?user=Vw31HP8AAAAJ">https://scholar.google.com/citations?user=Vw31HP8AAAAJ</a><o:p></o:p></li><li class="MsoListParagraph" style="margin-left:0cm;mso-list:l0 level1 lfo1"><span lang="ES">Guilherme Maia de Oliveira Wood (February 2025) -
<a href="https://homepage.uni-graz.at/en/guilherme.wood/">https://homepage.uni-graz.at/en/guilherme.wood/</a><o:p></o:p></span></li><li class="MsoListParagraph" style="margin-left:0cm;mso-list:l0 level1 lfo1">Selina Wriessnegger (March 2025) -
<span lang="ES"><a href="https://scholar.google.com/citations?user=Y_B7AnAAAAAJ"><span lang="EN-GB">https://scholar.google.com/citations?user=Y_B7AnAAAAAJ</span></a></span><o:p></o:p></li></ul>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">If you don’t want to miss our next webinars, please email <a href="mailto:amatra@essex.ac.uk">
amatra@essex.ac.uk</a> to ask to be added to our webinars mailing list.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Best wishes,<o:p></o:p></p>
<p class="MsoNormal">Ana<span style="font-size:11.0pt;mso-fareast-language:EN-US"><o:p></o:p></span></p>
<div>
<p class="MsoNormal" style="background:white"><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:black">------------------------</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Arial Black",sans-serif;color:#EE3424">Dr Ana Matran-Fernandez</span><span style="font-size:11.0pt;font-family:"Arial Black",sans-serif">
</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif">PhD</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Lecturer in Neural Engineering and Artificial Intelligence</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Department of Computer Science and Electronic Engineering (CSEE)</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">University of Essex</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif">Office: 5B.539</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial Black",sans-serif;color:#EE3424">E
</span><a href="mailto:amatra@essex.ac.uk" target="_blank"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">amatra@essex.ac.uk</span></a><span style="font-size:10.0pt;font-family:"Arial",sans-serif">
</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:black"> </span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><b><span style="font-size:9.0pt;font-family:"Tahoma",sans-serif;color:black">Email notices: </span></b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:9.0pt;font-family:"Tahoma",sans-serif;color:black">1) I sometimes write emails outside (your) working hours. Please don't take this as an indication that I require an immediate response -
we simply may be working at different times.</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:9.0pt;font-family:"Tahoma",sans-serif;color:black">2) Because of the daily high load of emails, I may take some time to reply to you. If it's important, I may take even more time, because
I want to provide an adequate response. If it's urgent, I'll try to reply quickly and maybe just with a very short email. No disrespect, just trying to be efficient - I'd understand if you did the same.</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
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