<html><head><meta http-equiv="content-type" content="text/html; charset=us-ascii"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div><p style="margin: 0px; font-stretch: normal; line-height: normal; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(25, 26, 25);">Most of the experiments in the olfactory literature, assume that the odorant identity is known.</p><p style="margin: 0px; font-stretch: normal; line-height: normal; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(25, 26, 25);">As such, prior arts have primarily focused on the representation of odorant syntactic information</p><p style="margin: 0px; font-stretch: normal; line-height: normal; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(25, 26, 25);">(i.e., concentration amplitude) and cannot, therefore, serve as baseline methods without a formal</p><p style="margin: 0px; font-stretch: normal; line-height: normal; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(25, 26, 25);">computational/theoretic model of odorant identity. In contrast we argue in the paper below that</p><p style="margin: 0px; font-stretch: normal; line-height: normal; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(25, 26, 25);">odor signal processing in the Early Olfactory System of the fruit fly, is mostly focussed on extracting</p><p style="margin: 0px; font-stretch: normal; line-height: normal; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(25, 26, 25);">semantic information.</p><p style="margin: 0px; font-stretch: normal; line-height: normal; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(25, 26, 25);">Consequently, we assert that olfactory research needs to shift from solely focusing on processing</p><p style="margin: 0px; font-stretch: normal; line-height: normal; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(25, 26, 25);">syntactic (or Shannon) information to processing semantic, i.e., odorant identity information.</p></div><br class="Apple-interchange-newline">Modeling and characterization of pure and odorant mixture<br>
processing in the <i>Drosophila</i> mushroom body calyx<br>
Aurel A. Lazar, Tingkai Liu, Chung-Heng Yeh and Yiyin Zhou<br><div><p style="margin: 0px; font-style: normal; font-variant-caps: normal; font-stretch: normal; font-size: 12px; line-height: normal; font-family: "Helvetica Neue"; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(30, 30, 30);"><span style="font-kerning: none"><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 24px;"></span></p><p style="margin: 0px; font-style: normal; font-variant-caps: normal; font-stretch: normal; font-size: 12px; line-height: normal; font-family: "Helvetica Neue"; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(30, 30, 30);"><span style="font-kerning: none"><br></span></p><div style="display: block;"><div style="-webkit-user-select: all; -webkit-user-drag: element; display: inline-block;" class="apple-rich-link" draggable="true" role="link" data-url="https://doi.org/10.3389/fphys.2024.1410946"><a style="border-radius:10px;font-family:-apple-system, Helvetica, Arial, sans-serif;display:block;-webkit-user-select:none;width:300px;user-select:none;-webkit-user-modify:read-only;user-modify:read-only;overflow:hidden;text-decoration:none;" class="lp-rich-link" rel="nofollow" href="https://doi.org/10.3389/fphys.2024.1410946" dir="ltr" role="button" draggable="false" width="300"><table style="table-layout:fixed;border-collapse:collapse;width:300px;background-color:#1A300D;font-family:-apple-system, Helvetica, Arial, sans-serif;" class="lp-rich-link-emailBaseTable" cellpadding="0" cellspacing="0" border="0" width="300"><tbody><tr><td vertical-align="center" align="center"><img style="width:300px;filter:brightness(0.97);height:74px;" width="300" height="74" draggable="false" class="lp-rich-link-mediaImage" alt="fphys-15-1410946-g001.jpg" src="cid:FD320D53-AD04-4ACB-89ED-2E45F947C3D9"></td></tr><tr><td vertical-align="center"><table bgcolor="#1A300D" cellpadding="0" cellspacing="0" width="300" style="table-layout:fixed;font-family:-apple-system, Helvetica, Arial, sans-serif;background-color:rgba(26, 48, 13, 1);-apple-color-filter:initial;" class="lp-rich-link-captionBar"><tbody><tr><td style="padding:8px 0px 8px 0px;" class="lp-rich-link-captionBar-textStackItem"><div style="max-width:100%;margin:0px 16px 0px 16px;overflow:hidden;" class="lp-rich-link-captionBar-textStack"><div style="word-wrap:break-word;font-weight:500;font-size:12px;overflow:hidden;text-overflow:ellipsis;text-align:left;" class="lp-rich-link-captionBar-textStack-topCaption-leading"><a rel="nofollow" href="https://doi.org/10.3389/fphys.2024.1410946" style="text-decoration: none" draggable="false"><font color="#FFFFFF" style="color: rgba(255, 255, 255, 0.847059);">Frontiers | Modeling and characterization of pure and odorant mixture processing in the Drosophila mushroom body calyx</font></a></div><div style="word-wrap:break-word;font-weight:400;font-size:11px;overflow:hidden;text-overflow:ellipsis;text-align:left;" class="lp-rich-link-captionBar-textStack-bottomCaption-leading"><a rel="nofollow" href="https://doi.org/10.3389/fphys.2024.1410946" style="text-decoration: none" draggable="false"><font color="#FFFFFF" style="color: rgba(255, 255, 255, 0.54902);">doi.org</font></a></div></div></td></tr></tbody></table></td></tr></tbody></table></a></div></div><p style="margin: 0px; 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font-style: normal; font-variant-caps: normal; font-stretch: normal; font-size: 12px; line-height: normal; font-family: "Helvetica Neue"; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-variant-emoji: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal; color: rgb(30, 30, 30);"><span style="font-kerning: none"><br></span></p></div>
<div><div><div><span class="css-1jxf684 r-bcqeeo r-1ttztb7 r-qvutc0 r-poiln3" style="border: 0px solid black; box-sizing: border-box; display: inline; font-stretch: inherit; line-height: inherit; font-size-adjust: inherit; font-kerning: inherit; font-variant-alternates: inherit; font-variant-ligatures: inherit; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-position: inherit; font-feature-settings: inherit; font-optical-sizing: inherit; font-variation-settings: inherit; list-style: none; margin: 0px; padding: 0px; position: relative; overflow-wrap: break-word; min-width: 0px; text-overflow: unset;"><span style="background-color: rgba(0, 0, 0, 0.03);"><font color="#0f1419"><span style="white-space-collapse: preserve;">Results in brief:</span></font></span></span></div><div><span class="css-1jxf684 r-bcqeeo r-1ttztb7 r-qvutc0 r-poiln3" style="border: 0px solid black; box-sizing: border-box; display: inline; font-stretch: inherit; line-height: inherit; font-size-adjust: inherit; font-kerning: inherit; font-variant-alternates: inherit; font-variant-ligatures: inherit; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-position: inherit; font-feature-settings: inherit; font-optical-sizing: inherit; font-variation-settings: inherit; list-style: none; margin: 0px; padding: 0px; position: relative; overflow-wrap: break-word; min-width: 0px; text-overflow: unset;"><span style="background-color: rgba(0, 0, 0, 0.03);"><font color="#0f1419"><span style="white-space-collapse: preserve;">(i) Odorant stimuli are modeled by their identity (semantics) and concentration amplitude (syntactic) information content.</span></font></span></span></div><div><span class="css-1jxf684 r-bcqeeo r-1ttztb7 r-qvutc0 r-poiln3" style="white-space: pre-wrap; border: 0px solid black; box-sizing: border-box; color: rgb(15, 20, 25); display: inline; font-stretch: inherit; line-height: inherit; font-size-adjust: inherit; font-kerning: inherit; font-variant-alternates: inherit; font-variant-ligatures: inherit; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-position: inherit; font-feature-settings: inherit; font-optical-sizing: inherit; font-variation-settings: inherit; list-style: none; margin: 0px; padding: 0px; position: relative; overflow-wrap: break-word; min-width: 0px; caret-color: rgb(15, 20, 25); text-overflow: unset;"><span style="background-color: rgba(0, 0, 0, 0.03);">(ii) The Antennal Lobe and Calyx jointly separate the odorant semantics from syntactic information.</span></span></div><div><span class="css-1jxf684 r-bcqeeo r-1ttztb7 r-qvutc0 r-poiln3" style="white-space: pre-wrap; border: 0px solid black; box-sizing: border-box; color: rgb(15, 20, 25); display: inline; font-stretch: inherit; line-height: inherit; font-size-adjust: inherit; font-kerning: inherit; font-variant-alternates: inherit; font-variant-ligatures: inherit; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-position: inherit; font-feature-settings: inherit; font-optical-sizing: inherit; font-variation-settings: inherit; list-style: none; margin: 0px; padding: 0px; position: relative; overflow-wrap: break-word; min-width: 0px; caret-color: rgb(15, 20, 25); text-overflow: unset;">(iii) The semantics info is mapped by the Calyx into a first spike sequence for easy memory access in the Mushroom Body.</span></div></div><div><br></div><div>Aurel<br><a href="http://www.bionet.ee.columbia.edu">http://www.bionet.ee.columbia.edu</a><br></div><div><br></div></div></body></html>