<div dir="ltr"><p style="margin:0cm;font-size:medium;font-family:"Times New Roman",serif;color:rgb(0,0,0);text-align:justify"><span style="font-family:Calibri,sans-serif">Are you interested in laying down the basis for developing breakthrough regenerative robotic technologies for restoring movement following neuromuscular injuries such as stroke? Are you passionate about investigating how skeletal muscles remodel their biological structure when exposed to electrical and mechanical stimuli over multiple weeks? Are you interested in doing so by combining advanced</span><span class="gmail-Apple-converted-space" style="font-family:Calibri,sans-serif"> </span><i style="font-family:Calibri,sans-serif">in vitro</i><span style="font-family:Calibri,sans-serif">techniques for tissue-engineering muscles from human induced pluripotent stem cells together with computational modelling techniques?</span><span class="gmail-Apple-converted-space" style="font-family:Calibri,sans-serif"> </span><br></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US"> </span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US">The Neuro-Mechanical Modeling and Engineering Lab (</span><span lang="EN-US"><a href="http://bit.ly/NMLab" style="color:purple">http://bit.ly/NMLab</a></span><span lang="EN-US">) is seeking for an outstanding PhD candidate fellow to work within our new<span class="gmail-Apple-converted-space"> </span></span><span lang="EN-US" style="font-size:11.5pt;background-image:none;background-position:0% 0%;background-size:auto;background-repeat:repeat;background-origin:padding-box;background-clip:border-box">Project<span class="gmail-Apple-converted-space"> </span></span><span lang="EN-US">ROBOREACTOR funded by the prestigious European Research Council (Consolidator Grant)</span><span lang="EN-US">. You will join an international team working on a novel and ambitious project at the frontiers of muscle neurophysiology, muscle tissue regeneration and regenerative robotics (</span><span lang="EN-US"><a href="http://bit.ly/NMLTube" style="color:purple">http://bit.ly/NMLTube</a></span><span lang="EN-US">).</span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><b><span lang="EN-US"> </span></b></p><h2 style="margin:0cm;break-after:avoid;font-size:13pt;font-family:Calibri,sans-serif;color:rgb(0,176,80);text-align:justify"><span lang="EN-US">The opening:</span><span lang="EN-US"></span></h2><p class="MsoNormal" style="margin:0cm 0cm 6pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US">We are seeking for a motivated person that<span class="gmail-Apple-converted-space"> </span></span><span lang="EN-US">understands the physiology of skeletal muscles and is</span><span lang="EN-US">enthusiastic about working in cell culture labs for creating<span class="gmail-Apple-converted-space"> </span></span><span lang="EN-US">tissue-</span><span lang="EN-US">engineered skeletal muscles<span class="gmail-Apple-converted-space"> </span><i>in vitro</i><span class="gmail-Apple-converted-space"> </span>from human induced pluripotent stem cells (hiPSCs).<span class="gmail-Apple-converted-space"> </span></span></p><p class="MsoNormal" style="margin:0cm 0cm 6pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US">We are also looking for someone who will design four-week eccentric training protocols for pacing the tissue-engineered muscles and analyze how these<span class="gmail-Apple-converted-space"> </span></span><span lang="EN-US">tissues remodel their morphology over time<span class="gmail-Apple-converted-space"> </span><i>e.g.</i>, genesis of sarcomeres (<i>i.e.</i>, in parallel and in series), phenotype (<i>i.e.</i>, fiber type transition between fast and slow types), and changes in tissue force-generating capacity.</span></p><p class="MsoNormal" style="margin:0cm 0cm 6pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US">We are also looking for somebody who can learn to use computational modelling to<span class="gmail-Apple-converted-space"> </span></span><span lang="EN-US">predict how tissue-engineered muscles remodel during the 4-week eccentric training.<span class="gmail-Apple-converted-space"> </span></span></p><p class="MsoNormal" style="margin:0cm 0cm 6pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US"> </span></p><h2 style="margin:2pt 0cm 6pt;break-after:avoid;font-size:13pt;font-family:Calibri,sans-serif;color:rgb(0,176,80)"><span lang="EN-US">Your tasks will be:</span></h2><ul type="disc" style="margin-bottom:0cm;color:rgb(0,0,0);margin-top:0cm"><li class="MsoNormal" style="margin:0cm;text-align:justify;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US">Design and conduct 4-week<span class="gmail-Apple-converted-space"> </span><i>in vitro</i><span class="gmail-Apple-converted-space"> </span>experiments on tissue-engineered skeletal muscle to mimic eccentric muscle training, incorporating both electrical and mechanical pacing.</span><span lang="EN-US"></span></li><li class="MsoNormal" style="margin:0cm;text-align:justify;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US">To characterize structural remodelling in the tissue-engineered muscles. This implies the ability of characterizing changes in tissue force-generating capacity, morphology, phenotype and myotrophic factors.<span class="gmail-Apple-converted-space"> </span></span></li><li class="MsoNormal" style="margin:0cm;text-align:justify;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US">Use the gathered data to establish computational models of muscle structural remodelling.</span><span lang="EN-US"></span></li></ul><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US"> </span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US">Your work will be facilitated by in-house expertise and mentorship. You will collaborate with top-scientists on aspects including muscle-on-a-chip and statistical modelling, giving large opportunity to perform impactful research!</span></p><p class="MsoNormal" style="margin:0cm 0cm 6pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US"> </span></p><h2 style="margin:2pt 0cm 6pt;break-after:avoid;font-size:13pt;font-family:Calibri,sans-serif;color:rgb(0,176,80)"><span lang="EN-US">Information and application</span></h2><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US">Apply by August 18th, 2024 from this link:</span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US"><br></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US"><a href="https://utwentecareers.nl/en/vacancies/1829/phd-position-in-characterization-of-structural-remodelling-in-tissue-engineered-human-skeletal-muscles-in-vitro-during-multi-week-eccentric-training/">https://utwentecareers.nl/en/vacancies/1829/phd-position-in-characterization-of-structural-remodelling-in-tissue-engineered-human-skeletal-muscles-in-vitro-during-multi-week-eccentric-training/</a><br></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US"><br></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US">Applications must include the following documents:</span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US"> </span></p><ul type="disc" style="margin-bottom:0cm;color:rgb(0,0,0);margin-top:0cm"><li class="MsoNormal" style="margin:0cm;text-align:justify;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US">A video (2-minute max) describing your scientific interests and why you want to apply for this position.<span class="gmail-Apple-converted-space"> </span></span></li><li class="MsoNormal" style="margin:0cm;text-align:justify;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US">A cover letter (1-page max) specifying how your experience and skills match the position as well as summarizing work in your masters.<span class="gmail-Apple-converted-space"> </span></span></li><li class="MsoNormal" style="margin:0cm;text-align:justify;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US">A CV including English proficiency level, nationality, visa requirements, date of birth, experience overview, and publication list.</span></li><li class="MsoNormal" style="margin:0cm;text-align:justify;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US">Contact information for at least two academic references. A support letter will be requested only if your application is considered.</span></li></ul><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US"> </span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0);text-align:justify"><span lang="EN-US">The first interview will take place in the week of September the 2nd. Start of the contract is expected as soon as possible and no later than December 2024. For questions, please contact Prof. Massimo Sartori, mail:<span class="gmail-Apple-converted-space"> </span></span><span lang="EN-US"><a href="mailto:m.sartori@utwente.nl" style="color:purple">m.sartori@utwente.nl</a></span><span lang="EN-US">. Please, only apply via the web platform and not via email.</span></p><p class="MsoNormal" style="margin:0cm 0cm 6pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US"><br></span></p><p class="MsoNormal" style="margin:0cm;font-size:11pt;font-family:Aptos,sans-serif;color:rgb(0,0,0)"><span style="font-family:Calibri,sans-serif">---<br>Massimo Sartori<br>Full Professor and Head of Chair, Neuromuscular Robotics</span></p><p class="MsoNormal" style="margin:0cm;font-size:11pt;font-family:Aptos,sans-serif;color:rgb(0,0,0)"><span style="font-family:Calibri,sans-serif">Lab Head, Neuromechanical Modeling and Engineering Lab<br></span><span style="font-size:5pt;font-family:Calibri,sans-serif"> <br></span><span style="font-family:Calibri,sans-serif">University of Twente</span><span lang="EN-US" style="font-family:Calibri,sans-serif">,<span class="gmail-Apple-converted-space"> </span></span><span style="font-family:Calibri,sans-serif">TechMed Centre</span><span lang="EN-US" style="font-family:Calibri,sans-serif">, Robotics Centre</span><span style="font-family:Calibri,sans-serif"><br>Faculty of Engineering Technology <br>Department of Biomechanical Engineering<br>7500 AE, The Netherlands<br></span><span style="font-size:5pt;font-family:Calibri,sans-serif"><br></span><span style="font-family:Calibri,sans-serif">Personal: <a href="https://people.utwente.nl/m.sartori"><span style="color:rgb(5,99,193)">https://people.utwente.nl/m.sartori</span></a><br>Lab:<span class="gmail-Apple-converted-space"> </span><a href="https://bit.ly/NMLab"><span style="color:rgb(5,99,193)">https://bit.ly/NMLab</span></a><br>YouTube:<span class="gmail-Apple-converted-space"> </span><a href="https://bit.ly/NMLTube"><span style="color:rgb(5,99,193)">https://bit.ly/NMLTube</span></a></span></p><p class="MsoNormal" style="margin:0cm;font-size:11pt;font-family:Aptos,sans-serif;color:rgb(0,0,0)"><span style="font-family:Calibri,sans-serif"> </span></p><p class="MsoNormal" style="margin:0cm;font-size:11pt;font-family:Aptos,sans-serif;color:rgb(0,0,0)"><span style="font-family:Calibri,sans-serif">!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!</span></p><p class="MsoNormal" style="margin:0cm;font-size:11pt;font-family:Aptos,sans-serif;color:rgb(0,0,0)"><span style="font-family:Calibri,sans-serif">Listen to our<span class="gmail-Apple-converted-space"> </span><a href="https://open.spotify.com/show/3dQjP4kQ9nM3IaD5pHYvxB?si=6d90a5aeb6eb485f"><span style="color:rgb(5,99,193)">podcast</span></a><span class="gmail-Apple-converted-space"> </span>on AI-powered Digital Human Twins!<br>Watch our<span class="gmail-Apple-converted-space"> </span><a href="https://ntr.nl/Focus/287/detail/Geprinte-benen/VPWON_1353472"><span style="color:rgb(5,99,193)">work</span></a><span class="gmail-Apple-converted-space"> </span>on bionic legs featured on Dutch TV!</span></p><p class="MsoNormal" style="margin:0cm;font-size:11pt;font-family:Aptos,sans-serif;color:rgb(0,0,0)"><span style="font-family:Calibri,sans-serif">!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!</span></p><p class="MsoNormal" style="margin:0cm;font-size:11pt;font-family:Aptos,sans-serif;color:rgb(0,0,0)"><span style="font-size:5pt;font-family:Calibri,sans-serif"> </span></p><p class="MsoNormal" style="margin:0cm;font-size:11pt;font-family:Aptos,sans-serif;color:rgb(0,0,0)"><span lang="EN-GB"></span></p><p class="MsoNormal" style="margin:0cm 0cm 6pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US"><img border="0" width="281" height="65" src="blob:https://mail.google.com/84851585-3a2f-4373-86ff-58e7401102f4" alt="A picture containing icon

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