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<span dir="auto" style="text-align:start" class="ContentPasted0">PhD Studentship in the Centre for Future Societies at the University of Hertfordshire</span></div>
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<div dir="auto" style="text-align:start" class="ContentPasted0">Application Deadline 19 May 2023</div>
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<a tabindex="-1" style="cursor: pointer; text-decoration: none; color: rgb(56, 88, 152);" class="ContentPasted0"></a></span>Project title: Low-cost, accessible neurostimulation, experiments and simulations</div>
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<div class="x11i5rnm xat24cr x1mh8g0r x1vvkbs xtlvy1s x126k92a" style="margin: 0.5em 0px 0px; overflow-wrap: break-word; font-family: "Segoe UI Historic", "Segoe UI", Helvetica, Arial, sans-serif; font-size: 15px; text-align: left; color: rgb(5, 5, 5); background-color: rgb(255, 255, 255);">
<div dir="auto" style="text-align:start" class="ContentPasted0">Supervisors: Dr Nada Yousif, Professor Volker Steuber</div>
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<div class="x11i5rnm xat24cr x1mh8g0r x1vvkbs xtlvy1s x126k92a" style="margin: 0.5em 0px 0px; overflow-wrap: break-word; font-family: "Segoe UI Historic", "Segoe UI", Helvetica, Arial, sans-serif; font-size: 15px; text-align: left; color: rgb(5, 5, 5); background-color: rgb(255, 255, 255);">
<div dir="auto" style="text-align:start" class="ContentPasted0">Originality: The proposed project would for the first time combine experimental cerebellar stimulation and computational modelling, to show the feasibility of low-cost, accessible non-invasive
neurostimulation for treating movement disorders.</div>
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<div class="x11i5rnm xat24cr x1mh8g0r x1vvkbs xtlvy1s x126k92a" style="margin: 0.5em 0px 0px; overflow-wrap: break-word; font-family: "Segoe UI Historic", "Segoe UI", Helvetica, Arial, sans-serif; font-size: 15px; text-align: left; color: rgb(5, 5, 5); background-color: rgb(255, 255, 255);">
<div dir="auto" style="text-align:start" class="ContentPasted0">Significance: The cerebellum is a critical structure for movement. We have previously shown that it is central in controlling pathological activity in epilepsy (Kros et al., Annals of Neurology
2015) and essential tremor (Yousif et al., PloS Comput Biol, 2017). Deep brain stimulation (DBS) has been used for decades to treat tremor (Benabid et al, 1998) and more recently epilepsy (Zangiabadi et al., Frontiers Neurology, 2019). However, DBS is a highly
invasive surgical technique targeting the thalamus, a structure inaccessible by non-invasive neurostimulation.</div>
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<div class="x11i5rnm xat24cr x1mh8g0r x1vvkbs xtlvy1s x126k92a" style="margin: 0.5em 0px 0px; overflow-wrap: break-word; font-family: "Segoe UI Historic", "Segoe UI", Helvetica, Arial, sans-serif; font-size: 15px; text-align: left; color: rgb(5, 5, 5); background-color: rgb(255, 255, 255);">
<div dir="auto" style="text-align:start" class="ContentPasted0">Rigour: The project would involve, 1) a detailed biophysical computational model of the cerebellum, based on our previous work, but extended to involve connected structures such as the thalamus;
2) experiments with human participants involving non-invasive electrical stimulation of the cerebellum during normal movement tasks to inform, validate and test the model. Together, this will lead to theoretically based, novel stimulation paradigms for a closed-loop
system.</div>
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<span dir="auto" style="text-align:start" class="ContentPasted0">Potential Contribution to Knowledge: We propose that cerebellar stimulation could provide a method of replacing DBS and inhibiting pathological brain activity, and that a model based closed-loop
system would provide an optimal approach.</span></div>
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<span style="font-size: 11pt; color: rgb(153, 153, 153);"><span style="color: rgb(153, 153, 153);">Volker Steuber</span></span><br>
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<span style="color: rgb(153, 153, 153);"></span><span style="font-size: 11pt; color: rgb(153, 153, 153);">Professor of Computational Neuroscience</span></div>
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<span style="color: rgb(153, 153, 153);"></span><span style="color: rgb(51, 51, 51);"></span><span style="font-size: 11pt; color: rgb(153, 153, 153);">Biocomputation Research Group</span></div>
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<span style="color: rgb(153, 153, 153);"></span><span style="color: rgb(51, 51, 51);"></span><span style="font-size: 11pt; color: rgb(153, 153, 153);">School of Physics, Engineering and Computer Science</span></div>
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<span style="color: rgb(153, 153, 153);"></span><span style="color: rgb(51, 51, 51);"></span><span style="font-size: 11pt; color: rgb(153, 153, 153);">University of Hertfordshire</span></div>
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