<div dir="ltr"><p class="MsoNormal" style="text-align:justify;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">Dear All,</span></p><p class="MsoNormal" style="text-align:justify;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black"><br></span></p><p class="MsoNormal" style="text-align:justify;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">Up to 11 PhD positions are open at BCAM - Basque Centre for
Applied Mathematics, Bilbao (Basque Country, Spain) under the Severo Ochoa
program. </span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">We invite students in Engineering, Mathematics,
Physics (or Biophysics), Computer Science, Neuroscience or related fields to
apply for projects within the Mathematical, Computational and Experimental
Neuroscience (MCEN) research group led by Ikerbasque Professor Serafim Rodrigues.
</span><span lang="EN-US" style="font-size:11pt"></span></p>

<p class="MsoNormal" style="text-align:justify;border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black"> </span></p>

<p class="MsoNormal" style="text-align:justify;border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">MCEN was created
with the mission to bridge the gap between mathematics and experimental
neuroscience and to crucially enable mathematicians to come closer to
neuroscientific experiments and understand the mathematical challenges in
neuroscience. We are an interdisciplinary research group that also includes an
experimental lab named NeuroMath. It is equipped with state-of-the-art
electrophysiology and a setup for the design and implementation of neuromorphic
analog circuits. </span></p>

<p class="MsoNormal" style="text-align:justify;border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black"> </span></p>

<p class="MsoNormal" style="text-align:justify;border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">MCEN promotes multidisciplinary
projects combining insights from neuroscience, mathematics, physics and
computation. <span style="color:black">The PhD student will work in one of our
research lines, namely:</span></span></p>

<p class="MsoNormal" style="text-align:justify;border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif"> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt 36pt;text-align:justify;border:none;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:"Noto Sans Symbols";color:black">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">     
</span></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">Developing
mathematics for neuroscience to explain neurophysiological </span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">observations<span style="color:black"> of both normal and pathological
brain states (e.g. epilepsy, Alzheimer’s Disease), as well as, determining
brain’s computational principles [1,2]. </span></span></p>

<div style="border:1pt none black;padding:0cm;margin-left:18pt;margin-right:0cm">

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt 18pt;text-align:justify;border-top:none;border-right:none;border-left:none;padding:0cm;border-bottom:0cm none black;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:"Noto Sans Symbols";color:black">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">     
</span></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">Developing
models at the interface between statistical physics and computer science to
determine theoretical principles of intelligent agents’ perception and behavior
in complex environments [3,4].</span><span lang="EN-US" style="font-size:11pt;color:black"></span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt 18pt;text-align:justify;border-top:none;border-right:none;border-left:none;padding:0cm;border-bottom:0cm none black;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:"Noto Sans Symbols";color:black">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">     
</span></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">Developing
advanced data-science methods based on topological and geometrical data
analysis to determine invariants of neuroscientific data [4].</span><span lang="EN-US" style="font-size:11pt;color:black"></span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt 18pt;text-align:justify;border-top:none;border-right:none;border-left:none;padding:0cm;border-bottom:0cm none black;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:"Noto Sans Symbols";color:black">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">     
</span></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">Developing
closed-loop machine-brain interfaces for alternative clinical therapies (e.g.
deep-brain stimulators for epilepsy) and analog neuromorphic circuits [5].</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt 18pt;text-align:justify;border:none;padding:0cm;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:"Noto Sans Symbols";color:black">●<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">     
</span></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">Finding
drug targets via molecular simulations of protein complexes [6]. This involves
understanding protein interfaces, and docking of small therapeutic molecules.</span><span lang="EN-US" style="font-size:11pt;color:black"></span></p>

</div>

<p class="MsoNormal" style="text-align:justify;border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><a name="_heading=h.gjdgxs"></a><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black"> </span></p>

<p class="MsoNormal" style="text-align:justify;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">The Candidate will be co-supervised by Prof. Serafim
Rodrigues, Dr. Miguel Aguilera and Dr. Rodrigo Azevedo. Contracts will be
4-year long and will also cover doctoral course tuition fees and predoctoral
mobility (up to 6,860€ in total). The candidate will profit from </span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">MCEN’s large network of collaborators in Europe (to name a few: France,
Germany, The Netherlands, Portugal, UK) and also outside of Europe (to name a
few: Brazil, Canada, Japan, Turkey, USA).</span><span lang="EN-US" style="font-size:11pt"></span></p>

<p class="MsoNormal" style="border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black"> </span></p>

<p class="MsoNormal" style="text-align:justify;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">Applications are open until 26 January 2023 and
incorporation is possible between Sept 2023 and Sept 2024 (more information </span><span lang="EN-US"><a href="http://www.bcamath.org/predoctoral2022/"><span style="font-size:11pt;font-family:Arial,sans-serif">here</span></a></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black">).
</span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">Interested candidates, who have already
completed their MSc degree or are in the process of completing it, should
contact Prof. Rodrigues:</span><span lang="EN-US"><a href="mailto:srodrigues@bcamath.org"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(5,99,193)">srodrigues@bcamath.org</span></a></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">, Dr. Aguilera </span><span lang="EN-US"><a href="mailto:sci@maguilera.net"><span style="font-size:11pt;font-family:Arial,sans-serif;color:windowtext">sci@maguilera.net</span></a></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">, Dr. Azevedo : <a href="mailto:razevedo@bcamath.org">razevedo@bcamath.org</a></span><span lang="EN-US" style="font-size:11pt"></span></p>

<p class="MsoNormal" style="border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black"> </span></p>

<p class="MsoNormal" style="border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><b><span lang="EN-US" style="font-family:Arial,sans-serif;color:black">References</span></b></p>

<div style="border:1pt none black;padding:0cm">

<p class="MsoNormal" style="border:none;padding:0cm;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:black">[1]<b> </b>M Desroches, J Rinzel and S Rodrigues,
<i>Classification of bursting patterns: A
tale of two ducks</i>, </span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:rgb(10,79,150)">PLoS
Comput Biol </span><b><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:black">18</span></b><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:black">(2):
e1009752, 2022. </span></p>

</div>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif">[2] S <span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Rodrigues, M Desroches, M Krupa, JM Cortes, TJ
Sejnowski and AB Ali, <i>Time-coded neurotransmitter
release at excitatory and inhibitory synapses</i>, </span><span style="color:rgb(46,117,181);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">PNAS</span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> <b>113</b>(8): E1108-E1115, 2016.</span></span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">[3] M Aguilera, SA Moosavi and H Shimazaki, <i>A unifying framework for mean-field theories of asymmetric kinetic
Ising systems</i>. </span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:rgb(46,117,181);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Nat Commun</span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> <b>12</b>(1): 1-12, 2021.</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:black">[4] Aguilera, M., & Bedia, M. G.
(2018). <i>Adaptation to criticality through
organizational invariance in embodied agents</i></span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:rgb(46,117,181)">. Scientific reports</span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:black">, <i>8</i>(1), 1-11</span><span lang="EN-US" style="font-size:10pt"></span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">[5] A Guidolin, M Desroches, JD Victor, KP Purpura and S Rodrigues, <i>Geometry of spiking patterns in early visual
cortex: a topological data analytic approach</i>, </span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:rgb(46,117,181);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">J Roy Soc Interface</span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> <b>19</b>(196): 20220677, 2022.</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">[6] V Salari, S Rodrigues, E Saglamyurek, C Simon and D Oblak, <i>Are Brain–Computer Interfaces Feasible With
Integrated Photonic Chips?</i>, </span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:rgb(46,117,181);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Front Neurosci</span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> <b>15:</b> 1710, 2022.</span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">[7] Z Liu, RA Moreira, A Dujmović, H Liu, B Yang, AB Poma and MA Nash, <i>Mapping mechanostable pulling geometries of
a therapeutic anticalin/CTLA-4 protein complex</i>, </span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;color:rgb(46,117,181);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Nano Lett</span><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> <b>22</b>(1): 179-187, 2021.</span><span lang="EN-US"></span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US"> </span></p>

<p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><span lang="EN-US" style="font-size:10pt;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> </span></p>

<p class="MsoNormal" style="border:none;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><b><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:black"> </span></b></p><div><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr">              
<div>
<span style="border-collapse:separate;line-height:normal;text-align:-webkit-auto;text-indent:0px"><span style="border-collapse:separate;line-height:normal;text-indent:0px"><div><div style="color:rgb(0,0,0);font-family:Helvetica;font-size:12px;font-style:normal;font-weight:normal;letter-spacing:normal;text-transform:none;white-space:normal;word-spacing:0px"><span style="font-size:15px;font-family:Calibri">Serafim Rodrigues</span></div><div><font face="Calibri"><div style="color:rgb(0,0,0);font-family:Helvetica;font-size:12px;font-style:normal;font-weight:normal;letter-spacing:normal;text-transform:none;white-space:normal;word-spacing:0px"><span style="font-family:Calibri;font-size:15px"><font color="#31557F">Ikerbasque Research Professor</font></span></div><div style="color:rgb(0,0,0);font-family:Helvetica;font-size:12px;font-style:normal;font-weight:normal;letter-spacing:normal;text-transform:none;white-space:normal;word-spacing:0px"><span style="font-family:Calibri;font-size:15px"><font color="#31557F">Mathematical, Computational and Experimental Neuroscience (MCEN) Group Leader<br></font><b>BCAM - <font color="#284FAE"></font></b><font color="#1769FD"><font color="#1C48E9">Basque Center for Applied Mathematics</font><br></font>Alameda de Mazarredo, 14<br>E-48009 Bilbao, Basque Country - Spain<br>Tel. +34 946 567 842</span></div><div style="color:rgb(0,0,0);font-family:Helvetica;font-size:12px;font-style:normal;font-weight:normal;letter-spacing:normal;text-transform:none;white-space:normal;word-spacing:0px"><font face="Calibri" size="4"><span style="font-size:15px"><a href="mailto:srodrigues@bcamath.org" target="_blank">srodrigues@bcamath.org</a> | <a href="http://www.bcamath.org/srodrigues" target="_blank">www.bcamath.org/srodrigues</a> | </span></font><a href="http://www.ikerbasque.net/serafim-rodrigues" style="font-size:15px;font-family:Calibri;text-align:-webkit-auto" target="_blank">www.ikerbasque.net/serafim-rodrigues</a></div><div style="color:rgb(0,0,0);font-family:Helvetica;font-size:12px;font-style:normal;font-weight:normal;letter-spacing:normal;text-transform:none;white-space:normal;word-spacing:0px"><font face="Calibri" color="#7F7F7F" size="4"><span style="font-size:15px"><b><i><br></i></b></span></font></div><div style="color:rgb(0,0,0);font-family:Helvetica;font-size:12px;font-style:normal;font-weight:normal;letter-spacing:normal;text-transform:none;white-space:normal;word-spacing:0px"><span style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif;font-size:small">Old Mathematicians never die</span><div style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif;font-size:small">They just "tend to infinity"</div><div style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif;font-size:small">-Anonymous</div><div style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif;font-size:small"><br></div></div><div style="color:rgb(0,0,0);font-family:Helvetica;font-size:12px;font-style:normal;font-weight:normal;letter-spacing:normal;text-transform:none;white-space:normal;word-spacing:0px"><span style="font-family:Calibri;font-size:15px"><font color="#7F7F7F"><b><i>(</i></b><i></i></font><i><font color="#0041F1">matematika</font><font color="#7F7F7F"> mugaz bestalde<b>)</b></font></i></span></div></font></div></div></span>
</span>
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