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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;font-weight:400">Postdoctoral position: The role of hearing loss in cognitive impairment and Alzheimer’s disease pathology</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;font-weight:400">A full-time post-doctoral position is available in the Coleman Memorial Laboratory of at the University of California,
San Francisco. The appointment is funded by a newly awarded NIH R01 grant to study potential contributions of hearing loss to cognitive impairment using a mouse model of Alzheimer’s disease. The project combines
<span style="background-color:rgb(255, 255, 255);display:inline !important">computational analyses of cell and network interactions with </span>large-scale
</span><span style="font-size:11pt;font-family:Arial;color:#000000;font-weight:400;font-style:italic">in vivo</span><span style="font-size:11pt;font-family:Arial;color:#000000;font-weight:400"> physiology, brain-wide histological analysis, and behavioral training.
The principal investigator for the project is Dr. James Bigelow, with co-investigators Drs. Andrea Hasenstaub and Christoph Kirst. To apply, please send a CV and brief statement of interest to james.bigelow@ucsf.edu. Applications will be considered on a rolling
basis.</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;font-weight:400;text-decoration:underline;text-decoration-skip-ink:none">Minimum qualifications:</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span>PhD in neuroscience, physiology, cell biology, biomedical engineering, or related field.</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span>Strong written and oral communication skills demonstrated by peer-reviewed publications and conference presentations.</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span>Interest and ability to compete for extramural funding.</span></p>
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<span style="font-size:11pt;font-family:Arial;color:#000000;font-weight:400"> </span></p>
<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;font-weight:400">Preference will be given to candidates with experience in one or more of the following areas:</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span style="font-style:italic">In vivo</span><span> physiology, especially acute and/or chronic recordings using multichannel electrode arrays (e.g., Neuropixels). Specific experience within
the auditory cortex or hippocampal complex is desirable. </span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span>Histological techniques, especially tissue clearing and brain-wide histological analysis using iDISCO or related pipelines.</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span>Behavioral assessment in Alzheimer’s model mice (e.g., spatial learning and memory)</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span>Hearing assessment via auditory brainstem response measurements.</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span>Computational techniques for assessing functional interaction among neurons within and between brain regions (e.g., Granger causality, ensemble detection).</span></p>
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<p dir="ltr" style="line-height:1.2;margin-top:0pt;margin-bottom:0pt"><span>Analyzing large, complex datasets using MATLAB or Python.</span></p>
</li></ul>
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