<div dir="ltr"><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:10.5pt;color:rgb(34,34,34)">Dear all,</span><span style="font-size:10.5pt;color:rgb(34,34,34)"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:10.5pt;color:rgb(34,34,34)"> </span><span style="font-size:10.5pt;color:rgb(34,34,34)"></span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:10.5pt;color:rgb(34,34,34)">An 8-month research associate position for developing computational models of disease progression in dementia patients is available within my lab.<b><br><br>About the project</b><br>The most ideal time to intervene with disease-modifying treatment is early on before significant neurodegenerative change and neuronal loss has occurred. However, another highly relevant consideration is improvements in subtype diagnosis i.e. determination of the type of neurodegenerative process giving rise to dementia.  Differentiation is crucial as there are different management trajectories for each disease; for example, neuroleptic drugs which are given to AD can be fatal in the DLB group. Promising preliminary data, using simulation of disease progression, suggest that we may be able to make an early diagnosis even when subtle changes cannot be detected with the current machine learning approach. Going beyond machine learning subtype classification, our study aims to develop a simulation-based model of disease progression that can facilitate early treatment of the disease leading to improved outcomes for patients and reduced overall healthcare costs.<br><br><b>Available RA position</b><br>As part of this project, the lab of Prof. Marcus Kaiser (<a href="http://www.dynamic-connectome.org/" target="_blank" style="color:rgb(149,79,114)"><span style="color:rgb(140,104,203)">http://www.dynamic-connectome.org/</span></a> ), with joint supervision from the lab of Prof. John-Paul Taylor (</span><span style="font-size:10.5pt;color:rgb(34,34,34)"><a href="https://www.lewybodylab.org/" target="_blank" style="color:rgb(149,79,114)"><span style="color:rgb(5,99,193)">https://www.lewybodylab.org/</span></a></span><span lang="EN-US" style="font-size:10.5pt;color:rgb(34,34,34)"> ), are seeking a talented and enthusiastic research assistant with a PhD awarded, or a PhD thesis about to be submitted, in computational biology or related subjects; prior experience in the neurosciences is desirable.<br>    <br>The aim of this joint project, between Newcastle University and Korea University, is to developing more accurate dementia progression models that can inform diagnosis and treatment of patients using neuroimaging data.<span class="gmail-Apple-converted-space"> </span><br><br>Good communication skills, very strong dynamics modelling skills, and a track record of previous peer-reviewed journal publications. You will have experience with neuroimaging and/or computer simulations.<span class="gmail-Apple-converted-space"> </span><br><br><b>Research Environment</b><br></span><span style="font-size:10.5pt;color:rgb(34,34,34)">Nottingham “the home of MRI” offers an excellent environment for imaging (<a href="https://www.nottingham.ac.uk/research/beacons-of-excellence/precision-imaging/" target="_blank" style="color:rgb(149,79,114)">https://www.nottingham.ac.uk/research/beacons-of-excellence/precision-imaging/</a>  and <a href="https://www.nottingham.ac.uk/research/groups/spmic/index.aspx" target="_blank" style="color:rgb(149,79,114)">https://www.nottingham.ac.uk/research/groups/spmic/index.aspx</a> ), is pioneering the use of neurotechnology for brain disorders (<a href="http://mindtech.org.uk/" target="_blank" style="color:rgb(149,79,114)">http://mindtech.org.uk/</a> ), hosts the Institute of Mental Health (<a href="https://www.institutemh.org.uk/" target="_blank" style="color:rgb(149,79,114)">https://www.institutemh.org.uk</a> ), and has a large group of faculty members including four full professors (Stephen Coombes, Mark van Rossum, Mark Humphries, Marcus Kaiser) in the area of computational/mathematical neuroscience. </span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><b><span lang="EN-US" style="font-size:10.5pt;color:rgb(34,34,34)">How to Apply</span></b><span lang="EN-US" style="font-size:10.5pt;color:rgb(34,34,34)"><br>Apply before 15 March 2022 at <a href="https://jobs.nottingham.ac.uk/Vacancy.aspx?id=37834&forced=2" style="color:rgb(149,79,114)">https://jobs.nottingham.ac.uk/Vacancy.aspx?id=37834&forced=2</a></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:10.5pt;color:rgb(34,34,34)"> </span><span style="font-size:10.5pt;color:rgb(34,34,34)"></span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:10.5pt;color:rgb(34,34,34)">For informal queries, please contact Dr Marcus Kaiser, <a href="mailto:Marcus.kaiser@nottingham.ac.uk" style="color:rgb(149,79,114)">Marcus.kaiser@nottingham.ac.uk</a><span class="gmail-Apple-converted-space"> </span> </span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="color:rgb(34,34,34)"> </span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:10.5pt">Best,</span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:10.5pt">  Marcus</span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:10.5pt"> </span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">--</span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><b><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(66,222,255)"><br>Marcus Kaiser, Ph.D. FRSB</span></b><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">  <a href="https://twitter.com/ConnectomeLab" title="https://twitter.com/ConnectomeLab" style="color:rgb(149,79,114)"><span style="color:rgb(0,0,57)">@ConnectomeLab</span></a></span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><b><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(9,13,38)">Professor of Neuroinformatics</span></b><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><b><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(9,13,38)">Precision Imaging Beacon, School of Medicine, University of Nottingham</span></b><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:9pt;font-family:Arial,sans-serif"> </span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)">Guanci Visiting Professor </span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)">Rui Jin Hospital, Shanghai Jiao Tong University, China</span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)"> </span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)">Book: Changing Connectomes</span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)"><a href="https://mitpress.mit.edu/books/changing-connectomes" title="https://mitpress.mit.edu/books/changing-connectomes" style="color:rgb(149,79,114)"><span style="color:rgb(3,56,109)">https://mitpress.mit.edu/books/changing-connectomes</span></a></span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)"> </span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="DE" style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)">Lab website:<br><a href="http://www.dynamic-connectome.org/" title="http://www.dynamic-connectome.org/" style="color:rgb(149,79,114)"><span style="color:rgb(3,56,109)">http://www.dynamic-connectome.org</span></a>/ </span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="DE" style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)"> </span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="font-size:9pt;font-family:Arial,sans-serif;color:rgb(9,13,38)">Neuroinformatics UK:<br><a href="http://www.neuroinformatics.org.uk/" title="http://www.neuroinformatics.org.uk/" style="color:rgb(149,79,114)"><span style="color:rgb(3,56,109)">http://www.neuroinformatics.org.uk/</span></a></span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:11pt"> </span><span style="font-size:11pt"></span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span style="color:rgb(34,34,34)"> </span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(34,34,34)"> </span><span style="color:rgb(34,34,34)"></span></p><p class="MsoNormal" style="margin:0cm;font-size:medium;font-family:Calibri,sans-serif;color:rgb(0,0,0)"> </p></div>