<div dir="ltr"><div><div><span id="gmail-m_-3030424426738479120gmail-m_6248975881832900978gmail-docs-internal-guid-c03cb5fe-7fff-c358-9422-1d263d33dc98"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="background-color:transparent;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap"><br></span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="background-color:transparent;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap">Dear all,  </span><br></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">We are excited to announce an upcoming Research Topic, jointly within Frontiers in Neuroinformatics and Frontiers in Computational Neuroscience, on “Neuroinformatics of Large-Scale Brain Modelling”. </span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">This Research Topic will document the various ways in which neuroinformatics approaches are being applied in large-scale brain modelling, informing readers on both established practices and emerging techniques. We seek Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, and Opinion articles that cover, but are not limited to, the following topics:</span></p><br><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">Ontologies, systems, and tools for definition and specification of large-scale neural models</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">New approaches to parameter optimization, parameter space exploration, and systematic tracking of simulation behaviour across parameter combinations</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">Informing neural models with genetic and multi-omic data from large-scale databases and individual patients/subjects</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">Systematic computational modelling studies on large numbers of subjects, and/or using large-scale open-access datasets (HCP, ABCD, etc.)</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">‘Hybrid’ modelling schemes that combine mean-field with spiking network models</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">‘Hybrid’ approaches to defining connectivity in large-scale brain models (e.g. supplementing tractography with microscopy data for higher-resolution subcortical connectivity structure)</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">Simulations using high-resolution neuroanatomical data from initiatives such as BigBrain, Allen Institute, etc. </span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">‘High-density’ (large number of regions; small parcels) connectome-based neural mass modelling</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">Other neuroinformatics challenges and solutions in large-scale brain simulations</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">Comparisons between detailed spiking/morphological simulations and neural mass model simulations</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">Comparisons between models based on high-resolution and low-resolution Allen atlas connectivities</span></p></li></ul><br><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Full details can be found on the research topic webpage at: </span><a href="http://www.frontiersin.org/research-topics/16641/neuroinformatics-of-large-scale-brain-modelling" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">www.frontiersin.org/research-topics/16641/neuroinformatics-of-large-scale-brain-modelling</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"> </span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">If you are considering submitting, please submit an abstract by </span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Fri 26 Feb 2021</span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">. Deadline for submission of full manuscripts is </span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Fri 30th July 2021</span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">. </span></p><br><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">We look forward to your hearing from you and sharing this exciting work with the community. </span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Your Research Topic co-editors, </span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">John Griffiths</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Padraig Gleeson</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Kelly Shen</span></p></span><br><div><br></div><div><br></div></div><div><br></div></div><br clear="all"><div><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><p><span style="font-size:10pt;color:rgb(127,127,127)">Dr. John D. Griffiths</span></p><p><span style="color:rgb(127,127,127);font-size:10pt">Independent Scientist </span><span style="color:rgb(127,127,127);font-size:10pt">@ Krembil Centre for Neuroinformatics, CAMH, Toronto</span></p><p><font color="#7f7f7f"><span style="font-size:13.3333px">Assistant Professor @ Department of Psychiatry & Institute of Medical Sciences, University of Toronto</span></font></p><p><span style="font-size:13.3333px;color:rgb(127,127,127)"><a href="http://www.grifflab.com" target="_blank">www.grifflab.com</a></span><br></p><p><br></p><p>~~~</p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap">Frontiers in Neuroinformatics </span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap">& Frontiers in Computational Neuroscience </span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap">joint Research Topic: </span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:700;font-style:italic;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap">“Neuroinformatics of Large-Scale Brain Modelling”</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><i>Eds. John Griffiths, Kelly Shen, Padraig Gleeson</i></span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><span style="border:none;display:inline-block;overflow:hidden;width:103px;height:122px"><img src="https://lh3.googleusercontent.com/2LLUYvamj1TTYeQLJgmeSVe1zaax7W8RVoNT4FyfXxLaflGO3hM7Ef25yBk3MuawqTmroWyT4LJHfVFf1Wp8glHpAc4YJx8hjhME7hWME-YnN2w-E-drVOJs7W2rNIXBJwOqrxpx" width="103" height="122" style="margin-left:0px;margin-top:0px"></span></span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-style:italic;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><b>Now accepting submissions! </b></span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap">Abstract deadline 26 Feb 2021. Manuscript deadline 30 July 2021.  </span></p><p><span></span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap">See topic page </span><a href="https://www.frontiersin.org/research-topics/16641/neuroinformatics-of-large-scale-brain-modelling" style="text-decoration:none" target="_blank"><span style="font-size:11pt;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre;white-space:pre-wrap">here</span></a><span style="font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap"> for more info </span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap"><br></span></p></div></div></div></div></div></div></div></div>