<div dir="ltr"><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div style="color:rgb(0,0,0);font-family:-webkit-standard"><div><div><div><p class="MsoNormal" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:11pt;color:rgb(34,34,34)">Dear all,</span><span style="color:rgb(34,34,34)"></span></p><p class="MsoNormal" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:11pt;color:rgb(34,34,34)"> </span><span style="color:rgb(34,34,34)"></span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(34,34,34)">a 2-year PostDoc position for developing
computational models of disease progression in dementia patients is
available within my <span class="gmail-il">lab</span>.<b><br>
<br>
<strong>About the project</strong></b><br>
The most ideal time to intervene with disease-modifying treatment is early on
before significant neurodegenerative change and neuronal loss has occurred.
However, another highly relevant consideration is improvements in subtype
diagnosis i.e. determination of the type of neurodegenerative process giving
rise to dementia.  Differentiation is crucial as there are different
management trajectories for each disease; for example, neuroleptic drugs which
are given to AD can be fatal in the DLB group. Promising preliminary data,
using simulation of disease progression, suggest that we may be able to make an
early diagnosis even when subtle changes cannot be detected with the current
machine learning approach. Going beyond machine learning subtype
classification, our study aims to develop a simulation-based model of disease
progression that can facilitate early treatment of the disease leading to
improved outcomes for patients and reduced overall healthcare costs.<br>
<br>
<strong>Available RA position</strong><br>
As part of this project, the <span class="gmail-il">lab</span> of Prof.
Marcus Kaiser (</span><span lang="EN-US" style="color:rgb(34,34,34)"><a href="http://www.dynamic-connectome.org/" target="_blank" style="color:blue"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(140,104,203)"><span style="text-decoration-line:none">http://www.dynamic-connectome.org/</span></span></a></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(34,34,34)"> ), with joint supervision from the <span class="gmail-il">lab</span> of Prof. John-Paul Taylor (</span><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(34,34,34)"><a href="https://www.lewybodylab.org/" target="_blank" style="color:blue"><span style="color:rgb(5,99,193)">https://www.<span class="gmail-il">lewybodylab</span>.org/</span></a></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(34,34,34)"> ), are seeking a talented and enthusiastic
research assistant with a PhD awarded, or a PhD thesis about to be submitted,
in computational biology or related subjects; prior experience in the
neurosciences is desirable.<br>
    <br>
The aim of this joint project, between Newcastle University and Korea
University, is to developing more accurate dementia progression models that can
inform diagnosis and treatment of patients using neuroimaging (MRI and PET)
data. Objectives of this position are, first, to observe brain network features
of dementia patients and how these features are changing with disease
progression. Second, to develop computational models of how structural and
functional connectivity will change over time in these patients. Third, testing
whether the models can reproduce the actual progression and to test different
hypotheses about the underlying causes of brain network changes. <br>
<br>
Good communication skills, very strong dynamics modelling skills, and a track
record of previous peer-reviewed journal publications. You will have experience
with neuroimaging and/or computer simulations. The position will include visits
to our collaborators in South Korea (Profs Cheol Han and Hyun-Ghang Jeong,
Korea University). <br>
<br>
<strong>Research Environment</strong><br>
Neuroinformatics at Newcastle University in the UK covers a range of topics
from electrophysiology to neuroimaging. We are among the pioneers in connectome
analysis and the establishment computational models to inform interventions in
patients, e.g. through the £10m Wellcome Trust/EPSRC-funded CANDO project. Our
strength is a close collaboration between computational, experimental, and
clinical researchers. We currently have a team of 13 faculty members in
the areas of Neuroinformatics and Neurotechnology: </span><span lang="EN-US" style="color:rgb(34,34,34)"><a href="http://neuroinformatics.ncl.ac.uk/" target="_blank" style="color:blue"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(140,104,203)"><span style="text-decoration-line:none">http://neuroinformatics.ncl.ac.uk/</span></span></a></span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:Calibri,sans-serif"><b><span lang="EN-US" style="color:rgb(34,34,34)">How to Apply<br>
</span></b><span lang="EN-US" style="color:rgb(34,34,34)">Apply
before 23 January 2020 at </span><a href="https://jobs.ncl.ac.uk/job/Newcastle-Research-Assistant-Associate-in-Computational-Modelling-Dementia-Progression/581938101/" style="color:blue">https://jobs.ncl.ac.uk/job/Newcastle-Research-Assistant-Associate-in-Computational-Modelling-Dementia-Progression/581938101/</a></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri,sans-serif"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(34,34,34)">For
informal queries, please contact Dr Marcus Kaiser, <a href="mailto:Marcus.Kaiser@ncl.ac.uk" style="color:blue">Marcus.Kaiser@ncl.ac.uk</a> </span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt">









</span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(34,34,34)"> </span><span lang="EN-US" style="color:rgb(34,34,34)"></span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt"><br></span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt"><br></span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt"><br></span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt">Best,</span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt">  Marcus</span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt"> </span></p></div><div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">--</span><span lang="EN-US" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt"> </span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">Marcus Kaiser, Ph.D.  FRSB  <a href="https://twitter.com/ConnectomeLab" style="color:rgb(0,0,106)">@ConnectomeLab</a></span><span lang="EN-US" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">Professor of Neuroinformatics</span><span lang="EN-US" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt;font-family:Arial,sans-serif">Interdisciplinary Computing and Complex Biosystems (ICOS) Research Group</span><span lang="EN-US" style="font-size:10.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">School of Computing</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">Urban Sciences Building</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">Newcastle University</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">1 Science Square</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">Science Central</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">Newcastle upon Tyne</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">NE4 5TG</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:13.5pt">UK</span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:13.5pt"> </span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="DE" style="font-size:13.5pt;font-family:Arial,sans-serif">Lab website:</span><span lang="DE" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif"><a href="http://www.dynamic-connectome.org/" style="color:rgb(0,0,106)"><span lang="DE">http://www.dynamic-connectome.org</span></a></span><span lang="DE" style="font-size:13.5pt;font-family:Arial,sans-serif">/ </span><span lang="DE" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="DE" style="font-size:13.5pt"> </span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="DE" style="font-size:13.5pt;font-family:Arial,sans-serif">Neuroinformatics@Newcastle:</span><span lang="DE" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif"><a href="http://neuroinformatics.ncl.ac.uk/" style="color:rgb(0,0,106)"><span lang="DE">http://neuroinformatics.ncl.ac.uk</span></a></span><span lang="DE" style="font-size:13.5pt;font-family:Arial,sans-serif">/ </span><span lang="DE" style="font-size:10.5pt;font-family:Arial,sans-serif"> </span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="DE" style="font-size:10.5pt;font-family:Arial,sans-serif"> </span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:13.5pt;font-family:Arial,sans-serif">Neuroinformatics UK:</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif"><a href="http://www.neuroinformatics.org.uk/" style="color:rgb(0,0,106)"><span lang="EN-GB">http://www.neuroinformatics.org.uk/</span></a></span><span style="font-size:13.5pt"></span></p></div></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:10.5pt"> </span></p></div><div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">Neuroinformatics one-year master programme:</span><span lang="EN-US" style="font-size:13.5pt"></span></p></div></div></div></div></div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:13.5pt"><a href="http://research.ncl.ac.uk/neuroinformatics/study" style="color:rgb(0,0,106)">http://research.ncl.ac.uk/neuroinformatics/study</a></span></p></div></div></div></div></div></div></div></div></div></div></div></div></div>