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<p class="MsoNormal"><b><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif;border:none windowtext 1.0pt;padding:0in;background:white">Scientist I – Neural Connectivity and Consciousness<br>
<br>
</span></b><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif;background:white">The Allen Institute for Brain Science is looking to add a Scientist I to our Modeling & Theory team. This scientist will work under the supervision of Stefan Mihalas
and will be part of a larger team led by Christof Koch which includes both experimental, theoretical and modeling work aimed at measuring the neural correlates of consciousness.</span><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif"><br>
<br>
<span style="background:white">The mouse brain has an intricate anatomical connectivity, which we have mapped in detail ( http://connectivity.brain-map.org/ ). Connectivity patterns have important consequences for synchronization between areas. Specifically,
a small number of strong, long range connections can shift the synchronization from local to global. Additionally, in the cortex we have characterized multiple types of inter-areal connections.</span><br>
<br>
<span style="background:white">How does this observed structure support conscious perception? More specifically, what elements of network connectivity are important to generate activity which is sufficiently complex and integrated to support consciousness?
We seek to hire a scientist to help us make progress towards answering this question.</span><br>
<br>
<b><u><span style="border:none windowtext 1.0pt;padding:0in;background:white">Position Summary<br>
<br>
</span></u></b><span style="background:white">The Scientist will work on coarse-grained models of cortical networks aiming to understand how the structure of inter-areal connections influences the complexity of the activity simulated on such networks and the
synchronization between different nodes, and if any features of the observed mesoscopic connectivity are particularly important.</span><br>
<br>
<span style="background:white">We use mouse as a model system and this position will focus on using coupled oscillator models with multiple types of long-range interactions and population statistics models and simulation tools (http://alleninstitute.github.io/dipde/).</span><br>
<br>
<span style="background:white">More specifically, the scientist will work to: (i) Simulate coupled oscillator models parameterized by mesoscopic connectivity measurements and analyze the complexity of localized perturbations to the model (“Zap and Zip”). (ii)
Simulate the cortical activity using population statistic methods and simplified area models. (iii) Analyze the importance of both the strength and type of connections between areas to these results, and the importance of specific nodes (for example claustrum).</span><br>
<br>
<span style="background:white">While modeling work is essential for this position, the capacity of the applicant to work in parallel on theoretical understanding of the obtained results is highly desired.</span><br>
<br>
<b><u><span style="border:none windowtext 1.0pt;padding:0in;background:white">Job Responsibilities<br>
<br>
</span></u></b></span><o:p></o:p></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l2 level1 lfo1;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Simulate cortical networks parameterized from experimental data coupled oscillator models as well as population statistics model.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l2 level1 lfo1;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Analyze how different measures of activity (e.g. the complexity of perturbations, the relation between local and long-range correlations, and other measures of activity
shown to be relevant for consciousness) relate to graph theoretical measures based on strength of connections, and multigraph measures relating to types of connections.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l2 level1 lfo1;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Compare the results of the simulations with theoretical models with a focus on integrated information theory (IIT).<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l2 level1 lfo1;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Interact and collaborate with experimental and computational team members that are investigating complementary aspects of the neuronal correlates of consciousness.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l2 level1 lfo1;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Maintain clear and accurate communication with supervisor and team members.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l2 level1 lfo1;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Publish/present findings in peer-reviewed journals/scientific conferences.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif"><br>
<br>
<o:p></o:p></span></p>
<p class="MsoNormal"><b><u><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif;border:none windowtext 1.0pt;padding:0in;background:white">Required Qualifications<br>
<br>
</span></u></b><o:p></o:p></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l1 level1 lfo2;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">PhD degree in computational neuroscience, physics, mathematics, applied mathematics or related field.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l1 level1 lfo2;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Strong background in scientific computing.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l1 level1 lfo2;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Strong publication record.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l1 level1 lfo2;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Experience in pursuing research projects in collaborative fashion.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l1 level1 lfo2;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Proven independent thinking and flexibility.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l1 level1 lfo2;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Strong written and verbal communication skills.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif"><br>
<br>
<o:p></o:p></span></p>
<p class="MsoNormal"><b><u><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif;border:none windowtext 1.0pt;padding:0in;background:white">Preferred Qualifications<br>
<br>
</span></u></b><o:p></o:p></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l0 level1 lfo3;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Experience in computational neuroscience is preferred.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:0in;text-indent:-.25in;mso-list:l0 level1 lfo3;vertical-align:baseline">
<![if !supportLists]><span style="font-size:10.0pt;font-family:Symbol"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif">Ability to meet aggressive timelines and deliverables in a collaborative environment<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif;background:white">It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship
status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected
by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Segoe UI",sans-serif;background:white"><o:p> </o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Stefan Mihalas</span></b><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><br>
</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Associate Investigator<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Allen Institute for Brain Science</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:blue"><a href="http://www.alleninstitute.org/" target="_blank"><b><span style="color:blue">www.alleninstitute.org</span></b></a></span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Affiliate Professor<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Department of Applied Mathematics<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">University of Washington</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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