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<p><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Applications are invited for a: </span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
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<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">POSTDOCTORAL POSITION at Aix-Marseille University (southern France)</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">under the joint mentoring of Dr. Demian Battaglia (Institute for Systems Neuroscience - INS) and Dr. Nicole Malfait (Institut de Neurosciences de la Timone -
INT).</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
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<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">This two-years position is funded by the project ANR (Agence National de la Recherche) “SENCE - Movement disorders in Parkinson’s disease: The role of
somatoSENsory deficits and CErebellar anomalies”, involving researchers from Aix-Marseille University and the University of Oxford, as well as clinicians of the Hôpital de la Timone (AP-HM). </span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
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<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">In the context of this project, behavioral, electrophysiological (EEG/subthalamic nucleus LFP) and neuroimaging data will be recorded in patients with
Parkinson's disease, under different medication (ON/OFF L-Dopa) and deep brain stimulation (DBS) conditions. In particular, effects of conventional continuous “open-loop” and "closed-loop" (adaptive) DBS will be contrasted. Rich<span class="Apple-converted-space"> </span></span><span style="font-family: Helvetica; font-size: 13px; text-size-adjust: auto; color: rgb(0, 0, 255);"><span style="color: rgb(0, 0, 0);">expertise</span><span class="Apple-converted-space"> </span>will
be<span class="Apple-converted-space"> </span><span style="color: rgb(0, 0, 0);">thus<span class="Apple-converted-space"> </span></span></span><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">ava</span><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">ilable in psychophysics
and electrophysiology of sensorimotor systems (Nicole Malfait, INT</span><span style="font-family: Helvetica; font-size: 13px; text-size-adjust: auto; color: rgb(0, 0, 255);">; Huiling Tan, University of Oxford</span><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">),
structural and functional neuroimaging analyses (Olivier Coulon</span><span style="font-family: Helvetica; font-size: 13px; text-size-adjust: auto; color: rgb(0, 0, 255);">, INT</span><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">),
basal ganglia involvement in sensorimotor coordination (Andrea Brovelli, INT),<span class="Apple-converted-space"> </span></span><span style="font-family: Helvetica; font-size: 13px; text-size-adjust: auto; color: rgb(0, 0, 255);">and DBS</span><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;"><span class="Apple-converted-space"> </span>(Alexandre
Eusebio, AP-HM</span><span style="font-family: Helvetica; font-size: 13px; text-size-adjust: auto; color: rgb(0, 0, 255);">; Huiling Tan, University of Oxford</span><span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">)
and theoretical and computational modelling of oscillating circuits dynamics (Demian Battaglia, INS).</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
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<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">The postdoctoral fellow will participate to the design of circuit models (mean-field and spiking) with realistic anatomy, including known basal ganglia/cortical
loops, as well as connections between basal ganglia and cerebellum, whose role has been until now only poorly studied. It has indeed recently been hypothesized that basal ganglia deregulation may directly interact with cerebellar predictive functions contributing to
movement disorders in Parkinsons’s disease.</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Computational simulations of extended BG–cortex–cerebellum circuits will be used to reverse engineer circuit mechanisms responsible for the transition
from normal to pathological oscillatory dynamics –also in relation to Dopamine levels– and to model and optimize the impact of adaptive deep brain stimulation protocols. </span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
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<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Candidates should have already acquired experience in the computational modelling of neural circuits during their PhD. Previous experience in the modelling
of BG circuits is a plus. Candidates should be able to work in a dynamic, interdisciplinary and international work environment.</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Salary corresponds to French national guidelines (~2K € net per month, experience-dependent), with travel and equipment funds.</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
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<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">The successful candidate will integrate the Theoretical Neuroscience Group at the Institute for Systems Neuroscience (INS), located on the same campus
as the Institut des Neuroscience de la Timone (INT) and the Hôpital de la Timone (AP-HM). The integrative and clinical neuroscience community in Marseille is among the most lively in Europe and Marseille is a vibrating city, with wonderful natural surroundings
and home to the largest French-speaking university in the world, with an emphasis on interdisciplinary studies.</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Interested candidates should send a cv, a brief description of qualifications and research interests and the name of two reference contacts to both the
co-directors:</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
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<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Demian Battaglia </span><a href="mailto:demian.battaglia@univ-amu.fr" target="_blank" style="font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">demian.battaglia@univ-amu.fr</a><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Nicole Malfait </span><a href="mailto:nicole.malfait@univ-amu.fr" target="_blank" style="font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">nicole.malfait@univ-amu.fr</a><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Feel free to inquire for further information.</span><br style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">
<span style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 13px; text-size-adjust: auto;">Applications from under-represented categories in STEM sciences are welcome and supported.</span><br>
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