<div dir="ltr"><span style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">Call for papers Special Issue on Statistical and Machine Learning Modeling in Computational Epigenetics@</span><span class="gmail-il" style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">BioMed</span><span style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline"><span> </span></span><span class="gmail-il" style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">Research</span><span style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline"><span> </span>International</span><div style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial"><br></div><div style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">The call is available at <a href="https://www.hindawi.com/journals/bmri/si/873738/cfp/" target="_blank" style="color:rgb(17,85,204)">https://www.hindawi.com/<wbr>journals/bmri/si/873738/cfp/</a></div><div style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial"><br></div><div style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">Special Issue on Statistical and Machine Learning Modeling in Computational Epigenetics<br></div><div style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial"><br></div><div style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">Epigenetics has recently emerged as one of the hottest fields in life sciences for studying heritable change in phenotype, gene function, or gene expression that are not directly encoded in the DNA itself. Up-to-date studies have shown that epigenetic modulations are fundamental in many developmental processes, from tissue and organ formation to allele-specific gene expression. When these normal epigenetic patterns modify, pattern of gene expression can be deregulated, and it has been proven that such mechanisms are central in several disorders and diseases, among which are psychiatric disorders, obesity, and etiology of a number of diseases such as cancer, schizophrenia, and Alzheimer, just to name a few. Today, thanks also to several large human epigenome projects, scientists have a better understanding of the basic principles of epigenetic mechanisms as well as their relevance to health disorders and disease. At the heart of this fascinating<span> </span><span class="gmail-il">research</span><span> </span>field are computational tools that, by analyzing complex genomic information, play an essential role in discovering evidences to define new assessable hypotheses. In particular, the literature at a glance shows the effectiveness of a combination of statistical and machine learning techniques in several epigenetic analyses. This special issue aims to host original papers and reviews on recent<span> </span><span class="gmail-il">research</span><span> </span>advances and the state-of-the-art methods in the fields of statistical and machine learning methodologies and algorithm design for the study of epigenetic mechanisms. Especially welcome are also software systems with a special emphasis on tools developed with the help of big data distributed processing framework like Hadoop and Spark to properly manage the huge amount of data coming from epigenome-scale experiments.<br><br>Potential topics include but are not limited to the following:Machine learning<br>Statistical learning theory<br>Fuzzy logic and systems<br>Neuro-fuzzy systems<br>Granular computing<br>Data mining<br>Probabilistic and statistical modelling<br>Algorithms designed for epigenomic big data<br>High-throughput data in the broad context of epigenomics<br>Analysis, modeling, and prediction of DNA methylation patterns<br>Analysis, modeling, and prediction of histone modifications in DNA sequences<br>Identification of abnormal DNA methylation within CpG islands in different diseases<br>Analysis of epigenetic marks in stem cells<br>Analysis of miRNA changes in cancer and other diseases<br>Simultaneous analysis of methylome and transcriptome<br>Analysis of reciprocal regulation of noncoding RNA and methylation<br>Study of the epigenetic role in metabolomics<br>Analysis of microbiome role in epigenetic regulation of gene expression<br><p style="border:0px none;margin:12px 0px;outline:none 0px;padding:0px;line-height:20px">Authors can submit their manuscripts through the Manuscript Tracking System at<font color="#000000" face="Minion W08 Regular_1167271, Times"><span style="font-size:17px"> <a href="https://mts.hindawi.com/submit/journals/bmri/computational.biology/acim/" target="_blank" style="color:rgb(17,85,204)">https://mts.hindawi.com/<wbr>submit/journals/bmri/<wbr>computational.biology/acim/</a></span></font></p><p style="border:0px none;margin:12px 0px;outline:none 0px;padding:0px;line-height:20px">Submission deadline:</p><p style="border:0px none;margin:12px 0px;outline:none 0px;padding:0px;line-height:20px">Friday, 2 March 2018</p><p style="border:0px none;margin:12px 0px;outline:none 0px;padding:0px;line-height:20px">Publication date:</p><p style="border:0px none;margin:12px 0px;outline:none 0px;padding:0px;line-height:20px">July 2018</p></div><div style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial"><div>Antonino Staiano</div><div>Department of Science and Technology</div><div>University of Naples Parthenope, Naples, Italy</div><div><a href="mailto:antonino.staiano@uniparthenope.it" target="_blank" style="color:rgb(17,85,204)">antonino.staiano@<wbr>uniparthenope.it</a></div><div>******************************<wbr>******************************<wbr>******************************<wbr>******************</div></div><br clear="all"><div><div class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr">Antonino Staiano, PhD<div>Assistant Professor</div><div>Dept. Science and Technology</div><div>University of Naples Parthenope, Italy</div></div></div></div>
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