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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>Dear colleagues:</span><o:p></o:p></p><p class=MsoNormal style='text-autospace:none'> <o:p></o:p></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>I’d like to draw your attention to an opening in my lab (Scientist 2-level equivalent to senior postdoc) at the <a href="http://www.alleninstitute.org/what-we-do/brain-science/">Allen Institute for Brain Science in Seattle (USA)</a> focusing on <b>computational modeling of cellular and circuit mechanisms in human epilepsy </b>(please find the job ad attached below). While the position is computational, this is a joint computational-experimental effort in collaboration with in-house experimental colleagues, neurologists and neurosurgeons.</span><span style='font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>This is part of an exciting new translational neuroscience effort at the Allen Institute.</span><span style='font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Interested parties can apply at <a href="http://www.alleninstitute.org/what-we-do/brain-science/careers/job-search/">this link</a> under the position “scientist II – translational neuroscience”.</span><o:p></o:p></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'> </span><o:p></o:p></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>Let me know if you have questions.</span><o:p></o:p></p><p class=MsoNormal><span style='font-size:11.0pt'> </span><o:p></o:p></p><p class=MsoNormal><span style='font-size:11.0pt'>Many thanks, Costas</span><o:p></o:p></p><p class=MsoNormal><span style='font-size:10.5pt;color:black'>—<o:p></o:p></span></p><div><p class=MsoNormal style='line-height:12.0pt;mso-line-height-rule:exactly'><b><span style='font-size:10.0pt;font-family:Arial'>Costas Anastassiou<o:p></o:p></span></b></p><p class=MsoNormal style='line-height:12.0pt;mso-line-height-rule:exactly'><span style='font-size:10.0pt;font-family:Arial'>Assistant Investigator<o:p></o:p></span></p><p class=MsoNormal style='margin-left:13.5pt;text-indent:-13.5pt;line-height:12.0pt;mso-line-height-rule:exactly'><b><span style='font-size:8.0pt;font-family:Arial;color:#60A7E5'>T:</span></b><b><span style='font-size:8.0pt;font-family:Arial;color:#006DB6'> </span></b><span style='font-size:10.0pt;font-family:Arial'>206.547.8434<o:p></o:p></span></p><p class=MsoNormal style='margin-left:13.5pt;text-indent:-13.5pt;line-height:12.0pt;mso-line-height-rule:exactly'><b><span style='font-size:8.0pt;font-family:Arial;color:#60A7E5'>E:</span></b><b><span style='font-size:8.0pt;font-family:Arial;color:#006DB6'> </span></b><a href="mailto:address@alleninstitute.org"><span style='font-size:10.0pt;font-family:Arial;color:#60A7E5'>costasa@alleninstitute.org</span></a><span style='font-size:10.0pt;font-family:Arial;color:#006DB6'><o:p></o:p></span></p><p class=MsoNormal style='line-height:12.0pt;mso-line-height-rule:exactly'><span style='font-size:10.0pt;font-family:Arial;color:#006DB6'><o:p> </o:p></span></p><p class=MsoNormal style='line-height:12.0pt;mso-line-height-rule:exactly'><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
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</v:shape><![endif]--><![if !vml]><span style='mso-ignore:vglayout'><table cellpadding=0 cellspacing=0 align=left><tr><td width=0 height=2></td></tr><tr><td></td><td><img width=146 height=35 src="cid:image002.png@01D2256E.F78E15C0" v:shapes="Picture_x0020_2"></td></tr></table></span><![endif]><span style='font-size:10.0pt;font-family:Arial;color:#006DB6'><o:p> </o:p></span></p><p class=MsoNormal style='line-height:12.0pt;mso-line-height-rule:exactly'><span style='font-size:10.0pt;font-family:Arial;color:#006DB6'><o:p> </o:p></span></p><p class=MsoNormal style='line-height:12.0pt;mso-line-height-rule:exactly'><span style='font-size:10.0pt;font-family:Arial;color:#006DB6'><o:p> </o:p></span></p><br style='mso-ignore:vglayout' clear=ALL><p class=MsoNormal style='line-height:12.0pt;mso-line-height-rule:exactly'><a href="alleninstitute.org"><span style='font-size:10.0pt;font-family:Arial;color:#60A7E5'>alleninstitute.org</span></a><span style='font-size:10.0pt;font-family:Arial;color:#60A7E5'><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.5pt;color:black'><o:p> </o:p></span></p></div><div><div><div><p class=MsoNormal><span style='font-size:10.0pt;font-family:Arial;color:black'>Professor (adj.) of Neurology</span><span style='font-size:10.5pt;color:black'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:Helvetica;color:black'>University of British Columbia, Vancouver BC, CA</span><span style='font-size:10.5pt;color:black'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:9.0pt;font-family:Helvetica;color:black'><a href="http://neuroscience.ubc.ca/people/Anastassiou">http://neuroscience.ubc.ca/people/Anastassiou</a><o:p></o:p></span></p></div></div></div><div style='border:none;border-bottom:double windowtext 2.25pt;padding:0in 0in 1.0pt 0in'><p class=MsoNormal><span style='font-size:10.5pt;color:black'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'> </span><o:p></o:p></p></div><p class=MsoNormal><span style='font-size:11.0pt'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Times New Roman"'>Our mission at the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. By implementing a team science approach on a large scale we strive to generate useful public resources, drive technological innovations and discover fundamental brain properties through integration of experiments, modeling and theory</span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><b><span style='font-family:"Times New Roman"'><o:p> </o:p></span></b></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><b><span style='font-family:"Times New Roman"'>POSITION SUMMARY<o:p></o:p></span></b></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><o:p> </o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Times New Roman"'>We are seeking to fill a position at the level of Scientist II to work on an exciting new translational neuroscience effort at the Institute focusing on cellular and circuit mechanisms of epileptogenesis in human hippocampus. To address these questions, computational modeling of the human epileptogenetic hippocampus will be pursued utilizing existing state-of-the-art modeling, simulation and visualization capabilities at the Institute (e.g. see [Schomburg, Anastassiou et al, <i>J Neurosci</i>, 2012; Reimann, Anastassiou et al, <i>Neuron</i>, 2013; Taxidis, Anastassiou et al, <i>Neuron</i>, 2015]). </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Times New Roman"'>The aim is to understand how synaptic, cellular and connectivity properties of pathological brain tissue give rise to pathophysiological network dynamics, and identify intervention targets to suppress pathological activity. Importantly, the computational effort will occur in parallel with novel <i>in vitro</i> experiments in human brain slices derived from pharmacoresistant patients undergoing surgery for treatment of refractory mesial temporal lobe epilepsy. This effort will be pursued in collaboration with in-house experimental colleagues as well as neurologists and neurosurgeons. </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-family:"Times New Roman"'> </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><b><span style='font-family:"Times New Roman"'>RESPONSIBILITIES</span></b><o:p></o:p></p><ul type=disc><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo3'><span style='font-family:"Times New Roman"'>Computational modeling of neurons and circuits. </span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo3'><span style='font-family:"Times New Roman"'>Design, implement and analyze large-scale network simulations. </span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo3'><span style='font-family:"Times New Roman"'>Publish/present findings in peer-reviewed journals/scientific conferences.</span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo3'><span style='font-family:"Times New Roman"'>Preparation of both written and oral reports on a regular basis. </span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo3'><span style='font-family:"Times New Roman"'>Maintain clear and accurate communication with supervisor and team members. </span><o:p></o:p></li></ul><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><b><span style='font-family:"Times New Roman"'>QUALIFICATIONS </span></b><o:p></o:p></p><ul type=disc><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo6'><span style='font-family:"Times New Roman"'>PhD degree in computational neuroscience, physics, biology, bioengineering or related fields. </span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo6'><span style='font-family:"Times New Roman"'>Strong background in scientific computing; experience in computational neuroscience is preferred, but other strong applicants will be considered (with background in computational physics, biophysics, and related disciplines). Experience with parallel computing is a plus as well as familiarity with high-level programming languages such as python. </span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo6'><span style='font-family:"Times New Roman"'>Ability to meet aggressive timelines and deliverables in a collaborative environment.</span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo6'><span style='font-family:"Times New Roman"'>Strong publication record.</span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo6'><span style='font-family:"Times New Roman"'>Experience in pursuing research projects in collaborative fashion. </span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo6'><span style='font-family:"Times New Roman"'>Proven independent thinking and flexibility.</span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo6'><span style='font-family:"Times New Roman"'>Familiarity with <i>in vitro</i> and <i>in vivo</i> electrophysiological monitoring techniques and data analyses.</span><o:p></o:p></li><li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l3 level1 lfo6'><span style='font-family:"Times New Roman"'>Strong written and verbal communication skills.</span><o:p></o:p></li></ul><p class=MsoNormal><span style='font-size:11.0pt'> </span><o:p></o:p></p></div></body></html>