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--></style></head><body bgcolor=white lang=EN-US link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>Scientist II opening in Computational Neuroscience<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>Lab headed by Dr. Costas Anastassiou<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>Allen Institute of Brain Science<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'> <o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>Do you want to make a difference in our understanding of brain disorders? Do you have a solid background in computational neuroscience/scientific computing/simulation-based research and curious about how the brain works? Are you able to meet aggressive timelines and deliverables in a collaborative environment? The laboratory headed by Dr. Costas Anastassiou at the Allen Institute is currently looking for a talented Scientist II to work on large-scale, biophysically detailed brain circuit simulations to explore the pathophysiology of epilepsy. Our mission at the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. By implementing a team science approach on a large scale we strive to generate useful public resources, drive technological innovations and discover fundamental brain properties through integration of experiments, modeling and theory.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-size:11.0pt'> </span></b><span style='font-size:11.0pt'><o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-size:11.0pt'>Position summary:</span></b><span style='font-size:11.0pt'><o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>We are seeking to fill a position at the level of Scientist II (SciII) to work on an exciting new translational neuroscience pilot project at the Institute. The goal of this project is to investigate cellular and circuit mechanisms of epileptogenesis in human hippocampus. To address these questions, we seek to develop a faithful computational model of the human epileptogenetic hippocampus consisting of a multitude of reconstructed, interconnected and biophysically faithful neurons emulating anatomical and dynamical characteristics of the pathological brain tissue. For examples of biophysically realistic network models as pursued in this work see [Schomburg, Anastassiou et al, <i>J Neurosci</i>, 2012; Reimann, Anastassiou et al, <i>Neuron</i>, 2013; Taxidis, Anastassiou et al, <i>Neuron</i>, 2015]. The aim of the computational model is to (i) understand how synaptic, cellular and connectivity properties of pathological brain tissue give rise to pathophysiological network dynamics, (ii) understand how pathophysiological dynamics are reflected on signals such as depth-, ECoG- and EEG-recordings, and (iii) identify intervention targets to abort or suppress pathological activity. Importantly, the computational effort will occur in parallel with novel <i>in vitro</i> experiments in brain slices derived from patients undergoing surgery for treatment refractory mesial temporal lobe epilepsy that will provide the data on which the computational modeling will be based. The project will be pursued in collaboration with in-house experimental colleagues as well as neurologists and neurosurgeons and has a guaranteed duration initially of 18 months beginning in the summer of 2016.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-size:11.0pt'> </span></b><span style='font-size:11.0pt'><o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-size:11.0pt'>Responsibilities:</span></b><span style='font-size:11.0pt'><o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Construct detailed biophysical models using cable theory and NEURON-software.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Design, implement and analyze large-scale network simulations.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Publish/present findings in peer-reviewed journals/scientific conferences.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Prepare written and oral reports on a regular basis. <o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Publish scientific findings in peer-reviewed journals and relevant conferences.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Maintain clear and accurate communication with supervisor and team members.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-size:11.0pt'> </span></b><span style='font-size:11.0pt'><o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-size:11.0pt'>Qualifications:</span></b><span style='font-size:11.0pt'><o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>PhD degree in computational neuroscience, physics, biology, bioengineering or related fields.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Strong background in scientific computing; experience in computational neuroscience is preferred, but other strong applicants will be considered (with background in computational physics, biophysics, and related disciplines). Experience with parallel computing is a plus as well as familiarity with high-level programming languages such as python.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Ability to meet aggressive timelines and deliverables in a collaborative environment.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Strong publication record.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Experience in pursuing research projects in collaborative fashion. <o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Proven independent thinking and flexibility.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Familiarity with <i>in vitro</i> and <i>in vivo</i> electrophysiological monitoring techniques and data analyses.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:11.0pt'>·</span><span style='font-size:11.0pt;font-family:"Times New Roman"'> </span><span style='font-size:11.0pt'>Strong written and verbal communication skills.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-size:11.0pt'> </span></b><span style='font-size:11.0pt'><o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><b><span style='font-size:11.0pt'>How to apply:</span></b><span style='font-size:11.0pt'><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'>Visit the <a href="https://www.alleninstitute.org/what-we-do/brain-science/careers/job-search/"><span style='color:#0B1081'>Allen Institute for Brain Science Careers website</span></a> and fill out your information for the Scientist II-position under “2200-Modeling, Analysis and Theory”.</span><span style='font-size:11.0pt'><o:p></o:p></span></p></div></body></html>