<html><head><meta http-equiv="Content-Type" content="text/html charset=windows-1252"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;">Interesting<div><br></div><div>With respect to the cortical column discussion we didn’t yet have (whether they exist or not), there were actually two papers published by Vernon Mountcastle in the late 1950s in which the cortical column idea was introduced.</div><div><br></div><div>The first included mostly the data, the second mostly the idea.</div><div><br></div><div>I once plotted literature citations for the two papers.  For the first 10 years, the data paper was cited much more than the theory paper.  However, 15 year out they crossed and now the data paper is almost never sited.</div><div><br></div><div>So, as mentioned earlier with Marr and Albus, perhaps it is a kind of theory envy in neuroscience, but it is not at all unusual in neuroscience  to have exactly the opposite be the case, that the data is forgotten and the theory persist.</div><div><br></div><div>Perhaps all this is leading to an interesting article (or perhaps book with a series of essays) on how physics and biology are similar and different.  Anyone interested?</div><div><br></div><div>As some of you probably know, Thomas Kuhn explicitly excluded biology in his analysis (as a physicist, obviously, he knew that field better).  I have often her biologists say that his analysis does not apply to biology at which point I tell him that it does, he just didn’t talk very much about pre-parigmatic science.</div><div><br></div><div>However, I believe that the conversation we have been having about the epistemology of physics and biology might be of considerable more general interest.  I know that this has been commented on by others before (Richard F for example), but I don’t know of any volume of essays on the subject.</div><div><br></div><div>Could be interesting</div><div><br></div><div>Jim</div><div><br></div><div><br></div><div><br><div><div>On Jan 28, 2014, at 10:30 AM, Carson Chow <<a href="mailto:ccchow@pitt.edu">ccchow@pitt.edu</a>> wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite">
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    <font face="Times New Roman, Times, serif">Hi Brad,<br>
      <br>
      Philip Anderson, Nobel Prize in Physics, once wrote that theory
      and experimental results should never be in the same paper. His
      reason was for the protection of the experiment because if the
      theory turns out wrong (as is often the case) then people often
      forget about the data. <br>
      <br>
      Carson<br>
      <br>
      <br>
      <br>
    </font>
    <div class="moz-cite-prefix">On 1/28/14 8:25 AM, Brad Wyble wrote:<br>
    </div>
    <blockquote cite="mid:CAHXqt=4rqrerWaucufmb5Wxtho9h_wrnEYQtqr3kQW1Zro_cyQ@mail.gmail.com" type="cite">
      <div dir="ltr">Thanks Randal, that's a great suggestion.  I'll ask
        my colleagues in physics for their perspective as well.  
        <div><br>
        </div>
        <div>-Brad</div>
        <div><br>
        </div>
        <div><br>
        </div>
      </div>
      <div class="gmail_extra">
        <br>
        <br>
        <div class="gmail_quote">On Mon, Jan 27, 2014 at 11:54 PM,
          Randal Koene <span dir="ltr"><<a moz-do-not-send="true" href="mailto:randal.a.koene@gmail.com" target="_blank">randal.a.koene@gmail.com</a>></span>
          wrote:<br>
          <blockquote class="gmail_quote" style="margin:0 0 0
            .8ex;border-left:1px #ccc solid;padding-left:1ex">
            <div dir="ltr">
              <div style="font-family:arial,sans-serif;font-size:13px">Hi
                Brad,</div>
              <span style="font-family:arial,sans-serif;font-size:13px">This
                reminds me of theoretical physics, where proposed models
                are expounded in papers, often without the ability to
                immediately carry out empirical tests of all the
                predictions. Subsequently, experiments are often
                designed to compare and contrast different models.</span>
              <div style="font-family:arial,sans-serif;font-size:13px">
                Perhaps a way to advance this is indeed to make the
                analogy with physics?</div>
              <div style="font-family:arial,sans-serif;font-size:13px">Cheers,</div>
              <div style="font-family:arial,sans-serif;font-size:13px">Randal</div>
            </div>
            <div class="gmail_extra"><br clear="all">
              <div>
                <div dir="ltr">
                  <div>Dr. Randal A. Koene</div>
                  <div><a moz-do-not-send="true" href="mailto:Randal.A.Koene@gmail.com" target="_blank">Randal.A.Koene@gmail.com</a> - <a moz-do-not-send="true" href="mailto:Randal.A.Koene@carboncopies.org" target="_blank">Randal.A.Koene@carboncopies.org</a></div>
                  <div><a moz-do-not-send="true" href="http://randalkoene.com/" target="_blank">http://randalkoene.com</a> -
                    <a moz-do-not-send="true" href="http://carboncopies.org/" target="_blank">http://carboncopies.org</a></div>
                </div>
              </div>
              <div>
                <div class="h5">
                  <br>
                  <br>
                  <div class="gmail_quote">On Mon, Jan 27, 2014 at 8:29
                    PM, Brad Wyble <span dir="ltr"><<a moz-do-not-send="true" href="mailto:bwyble@gmail.com" target="_blank">bwyble@gmail.com</a>></span>
                    wrote:<br>
                    <blockquote class="gmail_quote" style="margin:0 0 0
                      .8ex;border-left:1px #ccc solid;padding-left:1ex">
                      <div dir="ltr">Thank you Mark, I hadn't seen this
                        paper.  She includes this other point that
                        should have been in my list:
                        <div><br>
                        </div>
                        <div>
                          <div>"From a practical point of view, as noted
                            the time required to build </div>
                          <div>and analyze a computational model is
                            quite substantial and validation may </div>
                          <div>require teams. To delay model
                            presentation until validation has occurred </div>
                          <div>retards the development of the scientific
                            field. "  ----Carley (1999)</div>
                        </div>
                        <div> </div>
                        <div><br>
                        </div>
                        <div>And here is a citation for this paper.</div>
                        <div>Carley, Kathleen M., 1999. Validating
                          Computational Models. CASOS Working Paper, CMU<span><font color="#888888"><br>
                            </font></span></div>
                        <span><font color="#888888">
                            <div><br>
                            </div>
                            <div>-Brad</div>
                            <div><br>
                            </div>
                            <div><br>
                            </div>
                          </font></span></div>
                      <div>
                        <div>
                          <div class="gmail_extra"><br>
                            <br>
                            <div class="gmail_quote">On Mon, Jan 27,
                              2014 at 9:48 PM, Mark Orr <span dir="ltr"><<a moz-do-not-send="true" href="mailto:mo2259@columbia.edu" target="_blank">mo2259@columbia.edu</a>></span>
                              wrote:<br>
                              <blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px
                                #ccc solid;padding-left:1ex">
                                <div style="word-wrap:break-word">Brad, 
                                  <div>Kathleen Carley, at CMU, has a
                                    paper on this idea (from the 1990s),
                                    suggesting the same practice. See <a moz-do-not-send="true" href="http://www2.econ.iastate.edu/tesfatsi/EmpValid.Carley.pdf" target="_blank">http://www2.econ.iastate.edu/tesfatsi/EmpValid.Carley.pdf</a></div>
                                  <span><font color="#888888">
                                      <div><br>
                                      </div>
                                      <div>Mark</div>
                                    </font></span>
                                  <div>
                                    <div>
                                      <div><br>
                                        <div>
                                          <div>On Jan 27, 2014, at 9:39
                                            PM, Brad Wyble wrote:</div>
                                          <br>
                                          <blockquote type="cite">
                                            <div dir="ltr">
                                              Dear connectionists, 
                                              <div><br>
                                              </div>
                                              <div>I wanted to get some
                                                feedback regarding some
                                                recent ideas concerning
                                                the publication of
                                                models because I think
                                                that our current
                                                practices are slowing
                                                down the progress of
                                                theory.  At present, at
                                                least in many psychology
                                                journals, it is often
                                                expected that a
                                                computational modelling
                                                paper includes
                                                experimental evidence in
                                                favor of  a small
                                                handful of its own
                                                predictions.  While I am
                                                certainly in favor of
                                                 model testing, I have
                                                come to the suspicion
                                                that the practice of
                                                including empirical
                                                validation within the
                                                same paper as the
                                                initial model is
                                                problematic for several
                                                reasons:</div>
                                              <div><br>
                                              </div>
                                              <div>
                                                <div>It encourages the
                                                  creation only of
                                                  predictions that are
                                                  easy to test with the
                                                  techniques available
                                                  to the modeller.</div>
                                              </div>
                                              <div><br>
                                              </div>
                                              <div>It strongly
                                                encourages a practice of
                                                running an experiment,
                                                designing a model to fit
                                                those results, and then
                                                claiming this as a bona
                                                fide prediction.  </div>
                                              <div><br>
                                              </div>
                                              <div>It encourages a
                                                practice of running a
                                                battery of experiments
                                                and reporting only those
                                                that match the model's
                                                output.  </div>
                                              <div><br>
                                              </div>
                                              <div>It encourages the
                                                creation of predictions
                                                which cannot fail, and
                                                are therefore less
                                                informative</div>
                                              <div><br>
                                              </div>
                                              <div>It encourages a
                                                mindset that a model is
                                                a failure if all of its
                                                predictions are not
                                                validated, when in fact
                                                we actually learn more
                                                from a failed prediction
                                                than a successful one.</div>
                                              <div><br>
                                              </div>
                                              <div>
                                                It makes it easier for
                                                experimentalists to
                                                ignore models, since
                                                such modelling papers
                                                are "self contained". </div>
                                              <div><br>
                                              </div>
                                              <div>I was thinking that,
                                                instead of the current
                                                practice, it should be
                                                permissible and even
                                                encouraged that a
                                                modelling paper should
                                                not include empirical
                                                validation, but instead
                                                include a broader array
                                                of predictions.  Thus
                                                instead of 3
                                                successfully tested
                                                predictions from the
                                                PI's own lab, a model
                                                might include 10
                                                untested predictions for
                                                a variety of different
                                                experimental techniques.
                                                This practice will, I
                                                suspect, lead to the
                                                development of bolder
                                                theories, stronger
                                                tests, and most
                                                importantly, tighter
                                                ties between empiricists
                                                and theoreticians.    </div>
                                              <div><br>
                                              </div>
                                              <div>I am certainly not
                                                advocating that
                                                modellers shouldn't test
                                                their own models, but
                                                rather that it should be
                                                permissible to publish a
                                                model without testing it
                                                first. The testing paper
                                                could come later.  </div>
                                              <div><br>
                                              </div>
                                              <div>I also realize that
                                                this shift in
                                                publication expectations
                                                 wouldn't prevent the
                                                problems described
                                                above, but it would at
                                                least not reward them.  </div>
                                              <div><br>
                                              </div>
                                              <div>I also think that
                                                modellers should make a
                                                concerted effort to
                                                target empirical
                                                journals to increase the
                                                visibility of models.
                                                 This effort should
                                                coincide with a shift in
                                                writing style to make
                                                such models more
                                                accessible to non
                                                modellers.</div>
                                              <div><br>
                                              </div>
                                              <div>What do people think
                                                of this? If there is
                                                broad agreement, what
                                                would be the best way to
                                                communicate this desire
                                                to journal editors?</div>
                                              <div><br>
                                              </div>
                                              <div>Any advice welcome!</div>
                                              <div><br>
                                              </div>
                                              <div>
                                                -Brad<br>
                                              </div>
                                              <div><br>
                                              </div>
                                              <div><br>
                                              </div>
                                              <div><br>
                                              </div>
                                              <div>-- <br>
                                                <div dir="ltr">Brad
                                                  Wyble<br>
                                                  Assistant Professor<br>
                                                  Psychology Department<br>
                                                  Penn State University
                                                  <div><br>
                                                  </div>
                                                  <div><a moz-do-not-send="true" href="http://wyblelab.com/" target="_blank">http://wyblelab.com</a></div>
                                                </div>
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                            <div><br>
                            </div>
                            -- <br>
                            <div dir="ltr">Brad Wyble<br>
                              Assistant Professor<br>
                              Psychology Department<br>
                              Penn State University
                              <div><br>
                              </div>
                              <div><a moz-do-not-send="true" href="http://wyblelab.com/" target="_blank">http://wyblelab.com</a></div>
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        <div><br>
        </div>
        -- <br>
        <div dir="ltr">Brad Wyble<br>
          Assistant Professor<br>
          Psychology Department<br>
          Penn State University
          <div><br>
          </div>
          <div><a moz-do-not-send="true" href="http://wyblelab.com/" target="_blank">http://wyblelab.com</a></div>
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<div style="color: rgb(0, 0, 0); font-family: Helvetica;  font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><p class="MsoNormal"><o:p> </o:p></p><p class="MsoNormal"><o:p> </o:p></p><p class="MsoNormal"><span style="font-size: 14pt; font-family: Verdana; color: rgb(149, 0, 4);">Dr. James M. Bower Ph.D.</span><o:p></o:p></p><p class="MsoNormal"><span style="font-size: 11pt; font-family: 'Times New Roman';">Professor of Computational Neurobiology</span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman'; color: rgb(66, 0, 168);">Barshop Institute for Longevity and Aging Studies.</span><span style="font-family: 'Times New Roman';"><o:p></o:p></span></p><p class="MsoNormal"><span style="font-size: 11pt; font-family: 'Times New Roman';">15355 Lambda Drive</span><span style="font-family: 'Times New Roman';"><o:p></o:p></span></p><p class="MsoNormal"><span style="font-size: 11pt; font-family: 'Times New Roman';">University of Texas Health Science Center </span><span style="font-family: 'Times New Roman';"><o:p></o:p></span></p><p class="MsoNormal"><span style="font-size: 11pt; font-family: 'Times New Roman';">San Antonio, Texas  78245</span><span style="font-family: 'Times New Roman';"><o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman';"> </span></p><p class="MsoNormal"><b><span style="font-size: 13pt; font-family: 'Times New Roman';">Phone:  210 382 0553</span></b><span style="font-family: 'Times New Roman';"><o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman';">Email: <a href="mailto:bower@uthscsa.edu">bower@uthscsa.edu</a><o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman';">Web: <a href="http://www.bower-lab.org">http://www.bower-lab.org</a><o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman';">twitter: superid101<o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman';">linkedin: Jim Bower<o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman';"> </span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman'; color: rgb(177, 89, 19);">CONFIDENTIAL NOTICE:<o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman'; color: rgb(177, 89, 19);">The contents of this email and any attachments to it may be privileged or contain privileged and confidential information. This information is only for the viewing or use of the intended recipient. If you have received this e-mail in error or are not the intended recipient, you are hereby notified that any disclosure, copying, distribution or use of, or the taking of any action in reliance upon, any of the information contained in this e-mail, or<o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman'; color: rgb(177, 89, 19);">any of the attachments to this e-mail, is strictly prohibited and that this e-mail and all of the attachments to this e-mail, if any, must be<o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman'; color: rgb(177, 89, 19);">immediately returned to the sender or destroyed and, in either case, this e-mail and all attachments to this e-mail must be immediately deleted from your computer without making any copies hereof and any and all hard copies made must be destroyed. If you have received this e-mail in error, please notify the sender by e-mail immediately.</span><span style="font-family: 'Times New Roman';"><o:p></o:p></span></p><p class="MsoNormal"><span style="font-family: 'Times New Roman';"> </span></p></div>
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