<html><head><meta http-equiv="Content-Type" content="text/html charset=windows-1252"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div>Ivan thanks for the response,</div><div><br></div><div>Actually, the talks at the recent Neuroscience Meeting about the Brain Project either excluded modeling altogether - or declared we in the US could leave it to the Europeans. I am not in the least bit nationalistic - but, collecting data without having models (rather than imaginings) to indicate what to collect, is simply foolish, with many examples from history to demonstrate the foolishness. In fact, one of the primary proponents (and likely beneficiaries) of this Brain Project, who gave the big talk at Neuroscience on the project (showing lots of pretty pictures), started his talk by asking: “what have we really learned since Cajal, except that there are also inhibitory neurons?” Shocking, not only because Cajal actually suggested that there might be inhibitory neurons - in fact. To quote “Stupid is as stupid does”.</div><div><br></div><div>Forbes magazine estimated that finding the Higgs Boson cost over $13BB, conservatively. The Higgs experiment was absolutely the opposite of a Big Data experiment - In fact, can you imagine the amount of money and time that would have been required if one had simply decided to collect all data at all possible energy levels? The Higgs experiment is all the more remarkable because it had the nearly unified support of the high energy physics community, not that there weren’t and aren’t skeptics, but still, remarkable that the large majority could agree on the undertaking and effort. The reason is, of course, that there was a theory - that dealt with the particulars and the details - not generalities. In contrast, there is a GREAT DEAL of skepticism (me included) about the Brain Project - its politics and its effects (or lack therefore), within neuroscience. (of course, many people are burring their concerns in favor of tin cups - hoping). Neuroscience has had genome envy for ever - the connectome is their response - who says its all in the connections? (sorry ‘connectionists’) Where is the theory? Hebb? You should read Hebb if you haven’t - rather remarkable treatise. But very far from a theory.</div><div><br></div><div>If you want an honest answer to your question - I have not seen any good evidence so far that the approach works, and I deeply suspect that the nervous system is very much NOT like any machine we have built or designed to date. I don’t believe that Newton would have accomplished what he did, had he not, first, been a remarkable experimentalist, tinkering with real things. I feel the same way about Neuroscience. Having spent almost 30 years building realistic models of its cells and networks (and also doing experiments, as described in the article I linked to) we have made some small progress - but only by avoiding abstractions and paying attention to the details. OF course, most experimentalists and even most modelers have paid little or no attention. We have a sociological and structural problem that, in my opinion, only the right kind of models can fix, coupled with a real commitment to the biology - in all its complexity. And, as the model I linked tries to make clear - we also have to all agree to start working on common “community models’. But like big horn sheep, much safer to stand on your own peak and make a lot of noise. </div><div><br></div><div>You can predict with great accuracy the movement of the planets in the sky using circles linked to other circles - nice and easy math, and very adaptable model (just add more circles when you need more accuracy, and invent entities like equant points, etc). Problem is, without getting into the nasty math and reality of ellipses- you can’t possible know anything about gravity, or the origins of the solar system, or its various and eventual perturbations. </div><div><br></div><div>As I have been saying for 30 years: Beware Ptolemy and curve fitting.</div><div><br></div><div>The details of reality matter.</div><div><br></div><div>Jim</div><div><br></div><div><br></div><div><br></div><div><br></div><br><div><div>On Jan 24, 2014, at 7:02 PM, Ivan Raikov <<a href="mailto:ivan.g.raikov@gmail.com">ivan.g.raikov@gmail.com</a>> wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite"><meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"><div dir="ltr"><br><div class="gmail_extra">I think perhaps the objection to the Big Data approach is that it is applied to the exclusion of all other modelling approaches. While it is true that complete and detailed understanding of neurophysiology and anatomy is at the heart of neuroscience, a lot can be learned about signal propagation in excitable branching structures using statistical physics, and a lot can be learned about information representation and transmission in the brain using mathematical theories about distributed communicating processes. As these modelling approaches have been successfully used in various areas of science, wouldn't you agree that they can also be used to understand at least some of the fundamental properties of brain structures and processes? <br>
<br></div><div class="gmail_extra"> -Ivan Raikov<br></div><div class="gmail_extra"><br><div class="gmail_quote">On Sat, Jan 25, 2014 at 8:31 AM, james bower <span dir="ltr"><<a href="mailto:bower@uthscsa.edu" target="_blank">bower@uthscsa.edu</a>></span> wrote:<br>
<blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">[snip] <br></blockquote><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">
<div style="word-wrap:break-word"></div><div style="word-wrap:break-word"><div>An enormous amount of engineering and neuroscience continues to think that the feedforward pathway is from the sensors to the inside - rather than seeing this as the actual feedback loop. Might to some sound like a semantic quibble, but I assure you it is not.</div>
<div><br></div><div>If you believe as I do, that the brain solves very hard problems, in very sophisticated ways, that involve, in some sense the construction of complex models about the world and how it operates in the world, and that those models are manifest in the complex architecture of the brain - then simplified solutions are missing the point.</div>
<div><br></div><div>What that means inevitably, in my view, is that the only way we will ever understand what brain-like is, is to pay tremendous attention experimentally and in our models to the actual detailed anatomy and physiology of the brains circuits and cells.</div>
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