Connectionists: Neural models of antisaccade performance in schizophrenia and OCD

[Vassilis Cutsuridis]

Dear colleagues,

I would like to bring to your attention two papers of mine on neural
modelling of antisaccade performance of healthy controls, schizophrenia and
obsessive-compulsive disorder (OCD) patients.

Experimental studies show deficits in antisaccade performance of schizophrenia
and OCD patients : increased variability in saccade response times and
increased error rates.

In collaboration with two psychiatric research groups from Germany and
Greece, the mechanisms that give rise to these antisaccade performance
deficits were investigated.

This research has led a number of important discoveries on what goes wrong
in the decision making processes in psychiatric diseases:

   - Why is the antisaccade performance of schizophrenia and OCD patients
   so poor?
   - Why are latencies more variable and errors greater in schizophrenia
   and OCD patients than in controls?
   - Is the poor performance of schizophrenia and OCD suffering patients
   performing the antisaccade task is due to a deficit in the top-down
   inhibitory control of the erroneous response?
   - Is there a need for an additional STOP decision signal (inhibitory and
   top-down in nature) to suppress (or inhibit) the erroneous response in the
   antisaccade task when the correct antisaccade has been expressed first?


Both papers can be downloaded from here:


*Cutsuridis V. (2017). A Neural Accumulator Model of Antisaccade
Performance of Healthy Controls and Obsessive-Compulsive Disorder Patients.
In M. K. vanVugt, A. P. Banks, & W. G. Kennedy (Eds.). Proceedings of the
15th International Conference on Cognitive Modeling. Coventry, United
Kingdom: University of Warwick.
<http://vassiliscutsuridis.com/docs/Conference_papers/CutICCM2017.pdf>*

* <http://vassiliscutsuridis.com/docs/Conference_papers/CutICCM2017.pdf>*
*Cutsuridis V*, Kumari V, Ettinger, U. (2014). Antisaccade performance in
schizophrenia: A Neural Model of Decision Making in the Superior
Colliculus. *Front. Neurosci.*, 8:13.
<http://vassiliscutsuridis.com/docs/Journal_papers/CutVenEtt2014FrontNeurosci.pdf>


Comments, questions, etc are most welcome.


Best regards,
Vassilis


---

Dr Vassilis Cutsuridis
Senior Lecturer in Computer Science
School of Computer Science
University of Lincoln
Lincoln
UK


Tel: +44 (0) 1522 83 5701
Email: vcutsuridis at lincoln.ac.uk
Web: http://staff.lincoln.ac.uk/vcutsuridis
Personal web: http://www.vassiliscutsuridis.com/
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