Connectionists: how the brain works? (UNCLASSIFIED)

Fri Mar 21 11:39:04 EDT 2014

I agree that habituation effect ("orientation reaction/reflex")  by E.N.Sokolov and O.S.Vinogradova is very important for understanding how the brain works.
I would like to add to the nice discussion a reference to the last paper by Olga Vinogradova (she was a collaborator and co-author of E.N. Sokolov):
Vinogradova O.S. (2001) Hippocampus as comparator: role of the two input and two output systems of the hippocampus in selection and registration of information. Hippocampus, 11 (5) 578-98.
In this paper Olga summarises her experimental and theoretical findings on the role of the hippocampus (and theta-rhythm)  for information processing in the brain.

Roman Borisyuk, DSc, PhD
Professor of Computational Neuroscience
School of Computing and Mathematics
University of Plymouth
A224, Portland Sq
Plymouth, PL4 8AA
UK
Phone: +44 (0) 1752 584949
E-mail: RBorisyuk at plymouth.ac.uk

-----Original Message-----
From: Connectionists [mailto:connectionists-bounces at mailman.srv.cs.cmu.edu] On Behalf Of Kelley, Troy D CIV (US)
Sent: 21 March 2014 12:24
To: Mark H. Bickhard
Cc: connectionists at mailman.srv.cs.cmu.edu
Subject: Re: Connectionists: how the brain works? (UNCLASSIFIED)

Classification: UNCLASSIFIED
Caveats: NONE

Yes, Mark, I would argue that habituation is anticipatory prediction.  The
neuron creates a model of the incoming stimulus and the neuron is
essentially predicting that the next stimuli will be comparatively similar
to the previous stimulus. If this prediction is met, the neuron habituates.
That is a simple, low level, predictive model.

-----Original Message-----
From: Mark H. Bickhard [mailto:mhb0 at Lehigh.EDU]
Sent: Thursday, March 20, 2014 5:28 PM
To: Kelley, Troy D CIV (US)
Cc: Tsvi Achler; Andras Lorincz; bower at uthscsa.edu;
connectionists at mailman.srv.cs.cmu.edu
Subject: Re: Connectionists: how the brain works?

I would agree with the importance of Sokolov habituation, but there is more
than one way to understand and generalize from this phenomenon:

http://www.lehigh.edu/~mhb0/AnticipatoryBrain20Aug13.pdf

Mark H. Bickhard
Lehigh University
17 Memorial Drive East
Bethlehem, PA 18015
mark at bickhard.name
http://bickhard.ws/

On Mar 20, 2014, at 4:41 PM, Kelley, Troy D CIV (US) wrote:

We have found that the habituation algorithm that Sokolov discovered way
back in 1963 provides an useful place to start if one is trying to determine
how the brain works.  The algorithm, at the cellular level, is capable of
determining novelty and generating implicit predictions - which it then
habituates to. Additionally, it is capable of regenerating the original
response when re-exposed to the same stimuli.  All of these behaviors
provide an excellent framework at the cellular level for explain all sorts
of high level behaviors at the functional level.  And it fits the Ockham's
razor principle of using a single algorithm to explain a wide variety of
explicit behavior.

Troy D. Kelley
RDRL-HRS-E
Cognitive Robotics and Modeling Team Leader Human Research and Engineering
Directorate U.S. Army Research Laboratory Aberdeen, MD 21005 Phone
410-278-5869 or 410-278-6748 Note my new email address:
troy.d.kelley6.civ at mail.mil

On 3/20/14 10:41 AM, "Tsvi Achler" <achler at gmail.com> wrote:

> I think an Ockham's razor principle can be used to find the most
> optimal algorithm if it is interpreted to mean the model with the
> least amount of free parameters that captures the most phenomena.
> http://reason.cs.uiuc.edu/tsvi/Evaluating_Flexibility_of_Recognition.p
> df
> -Tsvi
>
> On Wed, Mar 19, 2014 at 10:37 PM, Andras Lorincz <lorincz at inf.elte.hu>
wrote:
>> Ockham works here via compressing both the algorithm and the structure.
>> Compressing the structure to stem cells means that the algorithm
>> should describe the development, the working, and the time dependent
>> structure of the brain. Not compressing the description of the
>> structure of the evolved brain is a different problem since it saves
>> the need for the description of the development, but the working.
>> Understanding the structure and the working of one part of the brain
>> requires the description of its communication that increases the
>> complexity of the description. By the way, this holds for the whole
>> brain, so we might have to include the body at least; a structural
>> minimist may wish to start from the genetic code, use that hint and
>> unfold the already compressed description. There are (many and
>> different) todos 'outside' ...
>>
>>
>> Andras
>>
>>
>>
>>
>> .
>>
>> ________________________________
>> From: Connectionists <connectionists-bounces at mailman.srv.cs.cmu.edu>
>> on behalf of james bower <bower at uthscsa.edu>
>> Sent: Thursday, March 20, 2014 3:33 AM
>>
>> To: Geoffrey Goodhill
>> Cc: connectionists at mailman.srv.cs.cmu.edu
>> Subject: Re: Connectionists: how the brain works?
>>
>> Geoffrey,
>>
>> Nice addition to the discussion actually introducing an interesting
>> angle on the question of brain organization (see below)  As you note,
>> reaction diffusion mechanisms and modeling have been quite successful
>> in replicating patterns seen in biology - especially interesting I
>> think is the modeling of patterns in slime molds, but also for very
>> general pattern formation in embryology.  However, more and more
>> detailed analysis of what is diffusing, what is sensing what is
>> diffusing, and what is reacting to substances once sensed -- all
>> linked to complex patterns of gene regulation and expression have
>> made it clear that actual embryological development is much much more
complex, as Turing himself clearly anticipated, as the quote you cite pretty
>> clearly indicates.   Clearly a smart guy.   But, I don't actually think
that
>> this is an application of Ochham's razor although it might appear to
>> be after the fact.  Just as Hodgkin and Huxley were not applying it
either in
>> their model of the action potential.   Turing apparently guessed (based
on a
>> lot of work at the time on pattern formation with reaction diffusion)
>> that such a mechanism might provide the natural basis for what
>> embryos do. Thus, just like for Hodgkin and Huxley, his model
>> resulted from a bio-physical insight, not an explicit attempt to
>> build a stripped down model for its own sake.  I  seriously doubt
>> that Turning would have claimed that he, or his models could more
>> effectively do what biology actually does in forming an embrio, or
substitute for the actual process.
>>
>> However, I think there is another interesting connection here to the
>> discussion on modeling the brain. Almost certainly communication and
>> organizational systems in early living beings were reaction diffusion
based.
>> This is still a dominant effect for many 'sensing' in small organisms.
>> Perhaps, therefore, one can look at nervous systems as structures
>> specifically developed to supersede reaction diffusion mechanisms,
>> thus superseding this very 'natural' but complexity limited type of
>> communication and organization.  What this means, I believe, is that
>> a simplified or abstracted physical or mathematical model of the
>> brain explicitly violates the evolutionary pressures responsible for
>> its structure.  Its where the wires go, what the wires do, and what
>> the receiving neuron does with the information that forms the basis
>> for neural computation, multiplied by a very large number.  And that
>> is dependent on the actual physical structure of those elements.
>>
>> One more point about smart guys,  as a young computational
>> neurobiologist I questioned how insightful John von Neumann actually
>> was because I was constantly hearing about a lecture he wrote (but
>> didn't give) at Yale suggesting that dendrites and neurons might be
>> digital ( John von Neumann's The Computer and the Brain. (New
>> Haven/London: Yale Univesity Press, 1958.) Very clearly a not very
>> insightful idea for a supposedly smart guy.  It wasn't until a few
>> years later, when I actually read the lecture - that I found out that
>> he ends by stating that this idea is almost certainly wrong, given
>> the likely nonlinearities in neuronal dendrites.  So von Neumann
>> didn't lack insight, the people who quoted him did.  It is a
>> remarkable fact that more than 60 years later, the majority of models of
so called neurons built by engineers AND neurobiologists don't consider
these nonlinearities.
>> The point being the same point, to the Hopfield, Mead, Feynman list,
>> we can now add Turing and von Neumann as suspecting that for
>> understanding, biology and the nervous system must be dealt with in their
full complexity.
>>
>> But thanks for the example from Turing - always nice to consider actual
>> examples.   :-)
>>
>> Jim
>>
>>
>>
>>
>>
>> On Mar 19, 2014, at 8:30 PM, Geoffrey Goodhill <g.goodhill at uq.edu.au>
wrote:
>>
>> Hi All,
>>
>> A great example of successful Ockham-inspired biology is Alan
>> Turing's model for pattern formation (spots, stripes etc) in
>> embryology (The chemical basis of morphogenesis, Phil Trans Roy Soc,
>> 1953). Turing introduced a physical mechanism for how inhomogeneous
>> spatial patterns can arise in a biological system from a spatially
>> homogeneous starting point,  based on the diffusion of morphogens. The
paper begins:
>>
>> "In this section a mathematical model of the growing embryo will be
>> described. This model will be a simplification and an idealization,
>> and consequently a falsification. It is to be hoped that the features
>> retained for discussion are those of greatest importance in the
>> present state of knowledge."
>>
>> The paper remained virtually uncited for its first 20 years following
>> publication, but since then has amassed 8000 citations (Google
>> Scholar). The subsequent discovery of huge quantities of molecular
>> detail in biological pattern formation have only reinforced the
>> importance of this relatively simple model, not because it explains
>> every system, but because the overarching concepts it introduced have
proved to be so fertile.
>>
>> Cheers,
>>
>> Geoff
>>
>>
>> On Mar 20, 2014, at 6:27 AM, Michael Arbib wrote:
>>
>> Ignoring the gross differences in circuitry between hippocampus and
>> cerebellum, etc., is not erring on the side of simplicity, it is
>> erring, period. Have you actually looked at a
>> Cajal/Sxentagothai-style drawing of their circuitry?
>>
>> At 01:07 PM 3/19/2014, Brian J Mingus wrote:
>>
>> Hi Jim,
>>
>> Focusing too much on the details is risky in and of itself. Optimal
>> compression requires a balance, and we can't compute what that
>> balance is (all models are wrong). One thing we can say for sure is
>> that we should err on the side of simplicity, and adding detail to
>> theories before simpler explanations have failed is not Ockham's
>> heuristic. That said it's still in the space of a Big Data fuzzy
>> science approach, where we throw as much data from as many levels of
>> analysis as we can come up with into a big pot and then construct a
>> theory. The thing to keep in mind is that when we start pruning this
>> model most of the details are going to disappear, because almost all
>> of them are irrelevant. Indeed, the size of the description that
>> includes all the details is almost infinite, whereas the length of
>> the description that explains almost all the variance is extremely
>> short, especially in comparison. This is why Ockham's razor is a good
>> heuristic. It helps prevent us from wasting time on unnecessary
>> details by suggesting that we only inquire as to the details once our
existing simpler theory has failed to work.
>>
>> On 3/14/14 3:40 PM, Michael Arbib wrote:
>>
>> At 11:17 AM 3/14/2014, Juyang Weng wrote:
>>
>> The brain uses a single architecture to do all brain functions we are
>> aware of!  It uses the same architecture to do vision, audition,
>> motor, reasoning, decision making, motivation (including pain
>> avoidance and pleasure seeking, novelty seeking, higher emotion, etc.).
>>
>>
>> Gosh -- and I thought cerebral cortex, hippocampus and cerebellum
>> were very different from each other.
>>
>>
>>

Troy D. Kelley
RDRL-HRS-E
Cognitive Robotics and Modeling Team Leader Human Research and Engineering
Directorate U.S. Army Research Laboratory Aberdeen, MD 21005 Phone
410-278-5869 or 410-278-6748 Note my new email address:
troy.d.kelley6.civ at mail.mil

Classification: UNCLASSIFIED
Caveats: NONE

________________________________
[http://www.plymouth.ac.uk/images/email_footer.gif]<http://www.plymouth.ac.uk/worldclass>

This email and any files with it are confidential and intended solely for the use of the recipient to whom it is addressed. If you are not the intended recipient then copying, distribution or other use of the information contained is strictly prohibited and you should not rely on it. If you have received this email in error please let the sender know immediately and delete it from your system(s). Internet emails are not necessarily secure. While we take every care, Plymouth University accepts no responsibility for viruses and it is your responsibility to scan emails and their attachments. Plymouth University does not accept responsibility for any changes made after it was sent. Nothing in this email or its attachments constitutes an order for goods or services unless accompanied by an official order form.